{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:41:08Z","timestamp":1785894068541,"version":"3.56.0"},"reference-count":37,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,1]]},"abstract":"<jats:p>A field trial was conducted in a Lyme disease-endemic area of New Jersey to determine the efficacy of a doxycyline hyclate rodent bait to prophylactically protect and cure small-mammal reservoirs and reduce infection rates in questing <jats:italic>Ixodes scapularis<\/jats:italic> ticks for <jats:italic>Borrelia burgdorferi<\/jats:italic> and <jats:italic>Anaplasma phagocytophilum<\/jats:italic>. The doxycycline-laden bait was formulated at a concentration of 500 mg\/kg and delivered during the immature tick feeding season in rodent-targeted bait boxes. The percentage of infected small mammals recovered from treated areas after 2 years of treatment was reduced by 86.9% for <jats:italic>B. burgdorferi<\/jats:italic> and 74% for <jats:italic>A. phagocytophilum<\/jats:italic>. Infection rates in questing nymphal ticks for both <jats:italic>B. burgdorferi<\/jats:italic> and <jats:italic>A. phagocytophilum<\/jats:italic> were reduced by 94.3% and 92%, respectively. Results from this study indicate that doxycycline-impregnated bait is an effective means of reducing infection rates for <jats:italic>B. burgdorferi<\/jats:italic> and <jats:italic>A. phagocytophilum<\/jats:italic> in both rodent reservoirs and questing <jats:italic>I. scapularis<\/jats:italic> ticks.<\/jats:p>","DOI":"10.4269\/ajtmh.2011.11-0292","type":"journal-article","created":{"date-parts":[[2011,12,5]],"date-time":"2011-12-05T18:05:03Z","timestamp":1323108303000},"page":"1114-1120","source":"Crossref","is-referenced-by-count":32,"title":["Elimination of Borrelia burgdorferi and Anaplasma phagocytophilum in Rodent Reservoirs and Ixodes scapularis Ticks Using a Doxycycline Hyclate-Laden Bait"],"prefix":"10.4269","volume":"85","author":[{"given":"Marc C.","family":"Dolan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry 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