{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:44:11Z","timestamp":1763747051211},"reference-count":22,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,1]]},"abstract":"<jats:p>Third generation cephalosporins are commonly used in the treatment of leptospirosis. The efficacy of first generation cephalosporins has been less well-studied. Susceptibility testing of 13 <jats:italic>Leptospira<\/jats:italic> strains (11 serovars) to cefazolin and cephalexin was conducted using broth microdilution. Median minimal inhibitory concentration (MIC) for cefazolin and cephalexin ranged from &lt; 0.016 to 2 \u03bcg\/mL (MIC<jats:sub>90<\/jats:sub> = 0.5 \u03bcg\/mL) and from 1 to 8 \u03bcg\/mL (MIC<jats:sub>90<\/jats:sub> = 8 \u03bcg\/mL), respectively. Efficacy of cefazolin and cephalexin in an acute lethal hamster model of leptospirosis was studied. Survival rates for cefazolin were 80%, 100%, and 100%, and survival rates for cephalexin were 50%, 80%, and 100% (treated with 5, 25, and 50 mg\/kg per day for 5 days, respectively). Each treatment group showed improved survival compared with no treatment (<jats:italic>P<\/jats:italic> &lt; 0.01), and none of the therapies, regardless of dose, was statistically significantly different than doxycycline. These results support a potential role for first generation cephalosporins as alternative therapies for leptospirosis.<\/jats:p>","DOI":"10.4269\/ajtmh.2011.11-0352","type":"journal-article","created":{"date-parts":[[2011,11,2]],"date-time":"2011-11-02T21:52:54Z","timestamp":1320270774000},"page":"905-908","source":"Crossref","is-referenced-by-count":10,"title":["In Vitro and In Vivo Activity of First Generation Cephalosporins Against Leptospira"],"prefix":"10.4269","volume":"85","author":[{"given":"Brande M.","family":"Harris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Blatz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary 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