{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T20:40:06Z","timestamp":1723063206422},"reference-count":9,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,1]]},"abstract":"<jats:p>We report an unusual case of visceral leishmaniasis occurring in a patient from Sichuan China. The patient presented with a remitting fever, anemia, and pancytopenia. The case was confirmed as visceral leishmaniasis by microscopical detection of the <jats:italic>Leishmania<\/jats:italic> species amastigote in bone marrow aspirate. The patient was treated with 10 mg\/kg\/day of sodium stibogluconate for 5 days, with no therapeutic response. As a result, the patient was treated with liposomal amphotericin B (LAB) at 10 mg\/day as an initial dosage. After treatment with an increasing drug dosage for 7 days, acute renal injury was evident as indicated by increased serum creatinine and urea nitrogen. LAB administration was discontinued until serum creatinine and serum urea nitrogen regressed on Day 15. Two maintenance treatments of 100 mg\/day LAB were given on Days 19 and 26 (total 870 mg, 14.5 mg\/kg). Bone marrow aspirate and clinical examination suggested total remission.<\/jats:p>","DOI":"10.4269\/ajtmh.2011.11-0449","type":"journal-article","created":{"date-parts":[[2011,12,5]],"date-time":"2011-12-05T18:05:03Z","timestamp":1323108303000},"page":"1035-1037","source":"Crossref","is-referenced-by-count":4,"title":["Acute Renal Injury as a Result of Liposomal Amphotericin B Treatment in Sodium Stibogluconate Unresponsive Visceral Leishmaniasis"],"prefix":"10.4269","volume":"85","author":[{"given":"Songtao","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Parasites Infect Dis","first-page":"181","article-title":"Epidemiological and clinical analysis of 166 kala-azar cases","volume":"18","author":"Zhang","year":"2010"},{"key":"R2","series-title":"Bull World Health Organ","first-page":"11","article-title":"Education is key to controlling visceral leishmaniasis","volume":"88","author":"Killick-Kendrick","year":"2010"},{"key":"R3","series-title":"Expert Rev Anti Infect Ther","first-page":"919","article-title":"Current diagnosis and treatment of visceral leishmaniasis","volume":"8","author":"Mondal","year":"2010"},{"key":"R4","series-title":"Lancet","first-page":"477","article-title":"Comparison of short-course multidrug treatment with standard therapy for visceral leishmaniasis in India: an open-label, non-inferiority, randomized controlled trial","volume":"377","author":"Sundar","year":"2011"},{"key":"R5","series-title":"Chin J Infect Chemother","first-page":"241","article-title":"Human leishmaniasis: a retrospective clinical analysis of 86 patients","volume":"9","author":"Kang","year":"2009"},{"key":"R6","series-title":"Clin Infect Dis","first-page":"917","article-title":"Liposomal amphotericin B for the treatment visceral leishmaniasis","volume":"43","author":"Bern","year":"2006"},{"key":"R7","series-title":"N Engl J Med","first-page":"504","article-title":"Single-dose liposomal amphotericin B for visceral leishmaniasis in India","volume":"362","author":"Sundar","year":"2010"},{"key":"R8","series-title":"Int J Antimicrob Agents","first-page":"67","article-title":"A single high dose treatment of kala-azar with AmBisome (amphotericin B lipid complex): a pilot study","volume":"17","author":"Thakur","year":"2001"},{"key":"R9","series-title":"Am J Trop Med Hyg","first-page":"357","article-title":"Effectiveness and safety of liposomal amphotericin B for visceral leishmaniasis under routine program conditions in Bihar, India","volume":"83","author":"Sinha","year":"2010"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/85\/6\/article-p1035.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/85\/6\/article-p1035.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/85\/6\/article-p1035.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:34:37Z","timestamp":1723059277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/85\/6\/article-p1035.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,1]]},"references-count":9,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.2011.11-0449","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2011,12,1]]}}}