{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:34:30Z","timestamp":1778776470751,"version":"3.51.4"},"reference-count":27,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3,1]]},"abstract":"<jats:p>Dengue fever is endemic to Trinidad and Tobago. A retrospective analysis of all adult admissions at a tertiary hospital in Trinidad treated for dengue during January 1\u2013December 31, 2008 was performed. A total of 186 patients were treated during this period: 98.9% (184) of the patients were thrombocytopenic; 45.2% were severely thrombocytopenic; 13 patients showed development of minor hemorrhage and only one case of major hemorrhage; platelet transfusion was given for 7% (13) of the cases; and 6 cases for which platelet transfusion was given did not show evidence of plasma leakage (12 of these cases did not show evidence of hemorrhage). There was a strong association between the lowest platelet value and hemoconcentration (\u03c7<jats:sup>2<\/jats:sup> = 13.16, <jats:italic>P<\/jats:italic> &lt; 0.025). No association was found between giving a platelet transfusion and hemoconcentration or hemorrhage. Thrombocytopenia seen in dengue resolves spontaneously and independent of any transfusion used.<\/jats:p>","DOI":"10.4269\/ajtmh.2012.10-0209","type":"journal-article","created":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T16:17:19Z","timestamp":1331223439000},"page":"531-535","source":"Crossref","is-referenced-by-count":12,"title":["Dengue Hemorrhagic Fever in Trinidad and Tobago: A Case for a Conservative Approach to Platelet Transfusion"],"prefix":"10.4269","volume":"86","author":[{"given":"Anu","family":"Sharma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Charles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dave","family":"Chadee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surujpaul","family":"Teelucksingh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Lancet Infect Dis","first-page":"33","article-title":"Dngue: an update","volume":"2","author":"Guzman","year":"2002"},{"key":"R2","series-title":"Impact of Dengue","author":"World Health Organization","year":"2009"},{"key":"R3","series-title":"Kass Handbook of Infectious Diseases: Exotic Virus Infections","first-page":"103","author":"Innis","year":"1995"},{"key":"R4","series-title":"J Med Entomol","first-page":"411","article-title":"Who do female Aedes aegypti (Diptera: Culicidae) feed preferentially and frequently on human blood?","volume":"38","author":"Harrington","year":"2001"},{"key":"R5","series-title":"Transfus Med","first-page":"66","article-title":"Is dengue a threat to the blood supply?","volume":"19","author":"Teo","year":"2009"},{"key":"R6","series-title":"J Vector Ecol","first-page":"158","article-title":"Landing periodicity of Aedes aegypti with implications for dengue transmission in Trinidad, West Indies","volume":"25","author":"Chadee","year":"2000"},{"key":"R7","series-title":"Science","first-page":"476","article-title":"Pathogenesis of dengue: challenges to molecular biology","volume":"239","author":"Halstead","year":"1988"},{"key":"R8","series-title":"Curr Top Microbiol Immunol","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-3-662-05783-4_8","article-title":"Antibody mediated enhancement of viral disease","volume":"260","author":"Sullivan","year":"2001"},{"key":"R9","series-title":"Clin Exp Immunol","first-page":"299","article-title":"Association of increased platelet associated immunoglobulins with thrombocytopenia and the severity of disease in secondary dengue virus infections","volume":"138","author":"Saito","year":"2004"},{"key":"R10","series-title":"E. 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