{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:27:49Z","timestamp":1789846069686,"version":"4.0.1"},"reference-count":51,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3,1]]},"abstract":"<jats:p>Visceral leishmaniasis (VL) is responsible for substantial morbidity and mortality and current available treatments have many limitations. The ability of VL infection to generate life-long immunity offers promise for the development of a VL vaccine. A VL vaccine candidate has recently completed phase I clinical trials. We constructed a computer simulation model to determine the potential economic value of a VL vaccine in the endemic region of Bihar state, India. Results found a potential vaccine to be cost-effective (and in many cases economically dominant, i.e., saving costs and providing health benefits) throughout a wide range of vaccination costs and vaccine efficacies, and VL risks. Overall, our study strongly supports the continued development of a VL vaccine.<\/jats:p>","DOI":"10.4269\/ajtmh.2012.10-0415","type":"journal-article","created":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T16:17:19Z","timestamp":1331223439000},"page":"417-425","source":"Crossref","is-referenced-by-count":50,"title":["The Economic Value of a Visceral Leishmaniasis Vaccine in Bihar State, India"],"prefix":"10.4269","volume":"86","author":[{"given":"Bruce Y.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina M.","family":"Bacon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirat","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Beth","family":"Kitchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana 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consequences of a neglected disease in a Bangladeshi community","volume":"69","author":"Ahluwalia","year":"2003"},{"key":"R5","series-title":"Trop Med Int Health","first-page":"1715","article-title":"Costs of patient management of visceral leishmaniasis in Muzaffarpur, Bihar, India","volume":"11","author":"Meheus","year":"2006"},{"key":"R6","series-title":"J Vector Borne Dis","first-page":"105","article-title":"Can visceral leishmaniasis be eliminated from Asia?","volume":"45","author":"Joshi","year":"2008"},{"key":"R7","series-title":"WHO Special Programme for Research and Training in Tropical Diseases (TDR): research to support the elimination of visceral leishmaniasis","author":"World Health Organization","year":"2007"},{"key":"R8","series-title":"Am J Trop Med Hyg","first-page":"689","article-title":"ABLE: a new and improved amphotericin B for visceral leishmaniasis?","volume":"80","author":"Berman","year":"2009"},{"key":"R9","series-title":"Clin Infect Dis","first-page":"1104","article-title":"Failure of pentavalent antimony in visceral leishmaniasis in India: report from the center of the Indian epidemic","volume":"31","author":"Sundar","year":"2000"},{"key":"R10","series-title":"Mem Inst Oswaldo Cruz","first-page":"1019","article-title":"Vector density and the control of kala-azar in Bihar, India","volume":"104","author":"Kumar","year":"2009"},{"key":"R11","series-title":"J Vector Borne Dis","first-page":"225","article-title":"A report on the indoor residual spraying (IRS) in the control of Phlebotomus argentipes, the vector of visceral leishmaniasis in Bihar (India): an initiative towards total elimination targeting 2015 (Series-1)","volume":"46","author":"Kumar","year":"2009"},{"key":"R12","series-title":"Kathmandu Univ Med J","first-page":"488","article-title":"Elimination of visceral leishmaniasis in Nepal: pipe-dreams and possibilities","volume":"4","author":"Joshi","year":"2006"},{"key":"R13","series-title":"J Glob Infect 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(Larchmt)","first-page":"360","article-title":"Visceral leishmaniasis: consequences to women in a Bangladeshi community","volume":"13","author":"Ahluwalia","year":"2004"},{"key":"R24","series-title":"Am J Trop Med Hyg","first-page":"184","article-title":"Factors associated with visceral leishmaniasis in Nepal: bed-net use is strongly protective","volume":"63","author":"Bern","year":"2000"},{"key":"R25","series-title":"Indian J Med Res","first-page":"295","article-title":"Challenges in the diagnosis of post kala-azar dermal leishmaniasis","volume":"123","author":"Salotra","year":"2006"},{"key":"R26","series-title":"Economics Survey 2009\u20132010","author":"Ministry of Finance Government of India","year":"2010"},{"key":"R27","series-title":"Am J Trop Med Hyg","first-page":"9","article-title":"Estimation of under-reporting of visceral leishmaniasis cases in Bihar, India","volume":"82","author":"Singh","year":"2010"},{"key":"R28","series-title":"Trop Med Int 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