{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:21:41Z","timestamp":1788448901566,"version":"build-2803163510"},"reference-count":37,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3,1]]},"abstract":"<jats:p>Disseminated sporotrichosis occurs in individuals with impaired cellular immunity, such as in cases of neoplasia, transplantation, diabetes, and especially, acquired immunodeficiency syndrome. This report presents a 32-year-old Brazilian human immunodeficiency virus (HIV)-infected patient who developed a protracted condition of disseminated sporotrichosis with endocarditis, bilateral endophthalmitis, and lymphatic involvement. He needed cardiac surgery to replace the mitral valve. <jats:italic>Sporothrix brasiliensis<\/jats:italic> isolates were recovered from cultures of subcutaneous nodules and mitral valve fragments. Species identification was based on classical and molecular methods. The patient received amphotericin B for 52 days and subsequently, oral itraconazole. He remains asymptomatic, and he is on maintenance therapy with itraconazole. Despite his positive clinical outcome, he developed bilateral blindness. To our knowledge, this case is the first report of endocarditis and endophthalmitis caused by <jats:italic>S. brasiliensis<\/jats:italic>.<\/jats:p>","DOI":"10.4269\/ajtmh.2012.11-0441","type":"journal-article","created":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T16:17:19Z","timestamp":1331223439000},"page":"477-480","source":"Crossref","is-referenced-by-count":84,"title":["Disseminated Sporothrix brasiliensis Infection with Endocardial and Ocular Involvement in an HIV-Infected Patient"],"prefix":"10.4269","volume":"86","author":[{"given":"Mario Le\u00f3n","family":"Silva-Vergara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoilo Pires","family":"de Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Ferreira","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel Reis","family":"Abdalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Nilsson","family":"Sgarbieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson Messias","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keila Cristina","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Hueb","family":"Barata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kennio","family":"Ferreira-Paim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Clin Infect Dis","first-page":"65","article-title":"Sporotrichosis in Peru: description of an area of hyperendemicity","volume":"30","author":"Pappas","year":"2000"},{"key":"R2","series-title":"Dermatologica","first-page":"209","article-title":"Survey of 200 cases of sporotrichosis","volume":"172","author":"Itoh","year":"1986"},{"key":"R3","series-title":"Mycopathologia","first-page":"113","article-title":"Epidemiology of sporotrichosis in Latin America","volume":"108","author":"Conti Diaz","year":"1989"},{"key":"R4","series-title":"J Clin Microbiol","first-page":"3251","article-title":"Molecular phylogeny of Sporothrix schenckii","volume":"44","author":"Marimon","year":"2006"},{"key":"R5","series-title":"Sporothrix brasiliensis, S. globosa, and S. mexicana, three new Sporothrix species of clinical interest. 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