{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:28:19Z","timestamp":1776904099746,"version":"3.51.2"},"reference-count":30,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,7,2]]},"abstract":"<jats:p>Patients who recover from leishmaniasis usually show development of strong immunity and induction of interferon-\u03b3 (IFN-\u03b3) and delayed type hypersensitivity. In a randomized trial, we analyzed the IFN-\u03b3 response by using a Quantiferon\u2013<jats:italic>Leishmania<\/jats:italic> assay against three <jats:italic>Leishmania<\/jats:italic> peptide antigens and compared it with results of the leishmanin skin test (LST) in persons residing in areas in Iran to which zoonotic cutaneous leishmaniasis (ZCL, 181 persons), anthroponotic cutaneous leishmaniasis (ACL, 104 persons), and zoonotic visceral leishmaniasis (ZVL, 67 persons) are endemic. The percentage of persons with an IFN-\u03b3-positive response (&gt; 0.2 IU\/mL) to three antigens and the mean concentration of IFN-\u03b3 induced by the antigens were higher for persons from areas endemic for ZVL than for persons from areas endemic for ZCL and ACL. The percentage of persons with LST-positive results (\u2265 5 mm indurations) was 99%, 94%, and 70% for areas with ZCL, ACL, and ZVL, respectively. Our data indicate that the LST is significantly more sensitive than IFN-\u03b3 levels in persons who have been cured of cutaneous leishmaniasis than in persons who have been cured of ZVL.<\/jats:p>","DOI":"10.4269\/ajtmh.2012.11-0479","type":"journal-article","created":{"date-parts":[[2012,7,4]],"date-time":"2012-07-04T20:56:49Z","timestamp":1341435409000},"page":"70-75","source":"Crossref","is-referenced-by-count":18,"title":["Assessment of Interferon-\u03b3 Levels and Leishmanin Skin Test Results in Persons Recovered for Leishmaniasis"],"prefix":"10.4269","volume":"87","author":[{"given":"Mohammad H.","family":"Alimohammadian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen L.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haideh","family":"Darabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhad","family":"Riazirad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soheila","family":"Ajdary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliakbar","family":"Shabani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad A.","family":"Rezaee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Mohebali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohreh","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farrokh","family":"Modabber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Lancet","first-page":"1561","article-title":"Advances in leishmaniasis","volume":"366","author":"Murray","year":"2005"},{"key":"R2","series-title":"Comp Immunol Microbiol Infect Dis","first-page":"305","article-title":"Leishmaniasis: current situation and new perspectives","volume":"27","author":"Desjeux","year":"2004"},{"key":"R3","series-title":"Acta Med Iran","first-page":"99","article-title":"A brief review of the epidemiology of various types of leishmaniasis in Iran","volume":"XIV","author":"Nadim","year":"1971"},{"key":"R4","series-title":"Annu Rev Immunol","first-page":"151","article-title":"The regulation of immunity to Leishmania major","volume":"13","author":"Reiner","year":"1995"},{"key":"R5","series-title":"Med Microbiol Immunol (Berl)","first-page":"1","article-title":"Immunobiology of experimental leishmaniasis","volume":"181","author":"Muller","year":"1992"},{"key":"R6","series-title":"Int Rev Immunol","first-page":"157","article-title":"Cytokines in parasitic diseases: the example of cutaneous leishmaniasis","volume":"17","author":"Launois","year":"1998"},{"key":"R7","series-title":"Clin Exp Immunol","first-page":"410","article-title":"Dichotomy of the human T cell response to Leishmania antigens. 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