{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T13:46:05Z","timestamp":1749735965184},"reference-count":17,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10,3]]},"abstract":"<jats:p>We analyzed the intensity of inflammation and parasitism in BALB\/c mice infected with <jats:italic>Trypanosoma cruzi<\/jats:italic> I stocks from Mexico with and without benznidazole treatment in the acute phase of disease. Heart and skeletal muscles were evaluated for parasites and inflammation and blood was evaluated for persistence of circulating parasites. Parasitemia was influenced by <jats:italic>T. cruzi<\/jats:italic> stocks used and benznidazole treatment. This treatment cleared circulating parasites three days after starting treatment when monitored by direct microscopy. There was a significant reduction of inflammation in skeletal muscles after benznidazole treatment in animals infected with Mexican <jats:italic>T. cruzi<\/jats:italic> I stocks (<jats:italic>P<\/jats:italic> &lt; 0.05), but this reduction was not significant in the heart (<jats:italic>P<\/jats:italic> &gt; 0.05). <jats:italic>Trypanosoma cruzi<\/jats:italic> I parasites from Mexico were demonstrated by polymerase chain reaction in tissues and blood of animals after benznidazole treatment.<\/jats:p>","DOI":"10.4269\/ajtmh.2012.11-0519","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T15:15:22Z","timestamp":1348240522000},"page":"671-674","source":"Crossref","is-referenced-by-count":1,"title":["Decreased Intensity of Inflammation in Benznidazole-Treated Mice Inoculated with Trypanosoma cruzi I Stocks from Mexico and Persistence of Circulating Parasites"],"prefix":"10.4269","volume":"87","author":[{"given":"Guillermo","family":"Cruz-Zetina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo","family":"del Rio-Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Ramos-Ligonio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Monteon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"issue":"(Suppl I)","key":"R1","series-title":"Mem Inst Oswaldo Cruz","first-page":"199","article-title":"Reflections on the population dymanics of Trypanosoma cruzi: heterogeneity versus 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Health","first-page":"141","article-title":"Cytokine expression at the inoculation site and nearby tissue an animal model infected with metacyclic trypomastigotes of Trypanosoma cruzi","volume":"37","author":"Monteon","year":"2009"},{"key":"R14","series-title":"Parasitology","first-page":"511","article-title":"Description of inflammation and cytokine profile at the inoculation site and in heart tissue of mice re-infected with Trypanosoma cruzi vector derived-metacyclic trypomastigotes","volume":"130","author":"G\u00f3mez-Garcia","year":"2005"},{"key":"R15","series-title":"Mem Inst Oswaldo Cruz","first-page":"1023","article-title":"Trypanosoma cruzi: parasite antigens sequestered in heart interstitial dendritic cells are related to persisting mycarditis in benznidazole-treated mice","volume":"107","author":"Siqueira","year":"2009"},{"key":"R16","series-title":"J Antimicrob Chemother","first-page":"1045","article-title":"Effects of specific treatment on parasitological and histopathological parameters in mice infected with different Trypanosoma cruzi clonal genotypes","volume":"53","author":"Toledo","year":"2004"},{"key":"R17","series-title":"J Antimicrob Chemother","first-page":"1319","article-title":"Persistence of PCR-positive tissue in beznidazole-treated mice with negative blood parasitological and serological tests in dual infections with Trypanosoma cruzi stocks from different genotypes","volume":"61","author":"Martins","year":"2008"}],"container-title":["The American Society of Tropical Medicine and 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