{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:02:48Z","timestamp":1723075368974},"reference-count":37,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:p>The purpose of this study was to correlate morphologic and hemodynamic Doppler ultrasound findings as indicators of the degree of inflammation and fibrosis and to diagnose chronic vital hepatitis complications and progression. A prospective, descriptive study of a case series was conducted that analyzed Doppler ultrasound images of the liver and portal system and used the portal vein congestion index, hepatic and splenic artery impedance indices, and the liver vascular index. Of 50 patients positive for antibodies against hepatitis C virus, morphologic changes highlighted increased hepatic parenchyma echogenicity in 24%, and increased gall blander echogenicity and wall thickness in 4%. The most common hemodynamic changes observed were reduced flow velocity in the portal vein trunk in 26%, congestion index changes in 12%, liver vascular index changes in 16%, and splenic and hepatic artery impedance index changes in 14%. These indices were shown to be associated with alanine aminotransferase levels, which suggested that they are important liver damage indicators in the early phase of infection with hepatitis C virus.<\/jats:p>","DOI":"10.4269\/ajtmh.2012.11-0561","type":"journal-article","created":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T21:50:37Z","timestamp":1328565037000},"page":"273-279","source":"Crossref","is-referenced-by-count":3,"title":["Non-Invasive Assessment of Fibrosis Using Color Doppler Ultrasound in Patients with Hepatitis C Virus in the Amazon Rainforest, Brazil"],"prefix":"10.4269","volume":"86","author":[{"given":"Jorge","family":"Le\u00e3o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Brock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia","family":"Castilho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Scariot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Scariot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wornei","family":"Braga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"article-title":"Hepatitis C","year":"2011","author":"World Health Organization","key":"R1"},{"year":"2008","series-title":"Hepatites Virais: O Brasil Est\u00e1 Atento","author":"Brasil","key":"R2"},{"key":"R3","first-page":"407","article-title":"Hepatites virais. Cimermam S, Cimermam B, eds. Medicina Tropical","author":"Gon\u00e7ales","year":"2003"},{"key":"R4","series-title":"Liver Disease","first-page":"3","article-title":"The natural history of hepatitis C","volume":"24","author":"Nezam","year":"2004"},{"key":"R5","series-title":"Am J Trop Med Hyg","first-page":"165","article-title":"Infection with hepatitis C virus among health care workers in the Brazilian Western Amazon Region (Rio Branco, State Of Acre)","volume":"76","author":"Paran\u00e1","year":"2007"},{"key":"R6","series-title":"Emerg Infect Dis","first-page":"676","article-title":"Hepatitis C virus in blood donors, Brazil","volume":"15","author":"Torres","year":"2009"},{"key":"R7","series-title":"Cad Saude Publica","first-page":"837","article-title":"Likely transmission of hepatitis C virus through sharing of cutting and perforating instruments in blood donors in the State of Par\u00e1, Northern Brazil","volume":"26","author":"De Oliveira-Filho","year":"2010"},{"key":"R8","first-page":"221","article-title":"Hepatite C epidemiologia. Foccacia R, ed. Tratado de Hepatites Virais","author":"Foccacia","year":"2003"},{"key":"R9","series-title":"Doppler hep\u00e1tico. Santos AA, Nacif MS, eds. Radiologia e Diagn\u00f3stico por Imagem: Abdome","first-page":"3","author":"Resende","year":"2005"},{"key":"R10","series-title":"Radiologia convencional e ultra-sonografia. Gayotto LC, Alves VA, eds. Doen\u00e7as do F\u00edgado e Vias Biliares","first-page":"173","author":"Vezozzo","year":"2001"},{"key":"R11","series-title":"Ultrasound Med Biol","first-page":"893","article-title":"Value of splanchnic Doppler ultrasound in the diagnosis of portal hypertension","volume":"27","author":"Piscaglia","year":"2001"},{"key":"R12","series-title":"AJR","first-page":"735","article-title":"Congestion index of the portal vein","volume":"146","author":"Moriyasu","year":"1986"},{"key":"R13","series-title":"Aliment Pharmacol Ther","first-page":"557","article-title":"Systematic review: non-invasive methods of fibrosis analysis in chronic hepatitis C","volume":"30","author":"Smith","year":"2009"},{"key":"R14","series-title":"World J Gastroenterol","first-page":"1898","article-title":"Portal hemodynamics as predictors of high risk esophageal varices in cirrhotic patients","volume":"14","author":"Tarzamni","year":"2008"},{"key":"R15","series-title":"Anatomia vascular do f\u00edgado. Nectoux JL, ed. Ultra-Sonografia Vascular","first-page":"305","author":"Maia","year":"2000"},{"year":"2003","series-title":"Introdu\u00e7\u00e3o \u00e0 Ultra-Sonografia Vascular","author":"Zwiebel","key":"R16"},{"key":"R17","series-title":"Clin Radiol","first-page":"1056","article-title":"Non-invasive evaluation of liver cirrhosis using ultrasound","volume":"64","author":"Goyal","year":"2009"},{"key":"R18","series-title":"Am J Gastroenterol","first-page":"1012","article-title":"Value of Doppler ultrasound parameters of portal vein and hepatic artery in the diagnosis of cirrhosis and portal hypertension","volume":"92","author":"Iwao","year":"1997"},{"key":"R19","series-title":"Am J Gastroenterol","first-page":"1853","article-title":"Prognostic significance of hepatic vein waveform by Doppler ultrasonography in cirrhotic patients with portal hypertension","volume":"90","author":"Ohta","year":"1995"},{"key":"R20","series-title":"Radiol Bras","first-page":"1","article-title":"Dopplerfluxometria da veia hep\u00e1tica em pacientes com esteatose n\u00e3o alco\u00f3lica","volume":"44","author":"Borges","year":"2011"},{"key":"R21","series-title":"Australas Radiol","first-page":"331","article-title":"Identification of hepatic cirrhosis by duplex Doppler ultrasound value of the hepatic artery resistive index","volume":"34","author":"Pierce","year":"1990"},{"key":"R22","series-title":"Gastroenterology","first-page":"1152","article-title":"Hepatic arterial resistance in cirrhosis with and without portal vein thrombosis: relationships with portal hemodynamics","volume":"108","author":"Sacerdoti","year":"1995"},{"year":"2004","series-title":"Hepatites B e C em Manaus: Perfil Cl\u00ednico-Epidemiol\u00f3gico e Distribui\u00e7\u00e3o Espacial de Casos Conhecidos Desde 1997 a 2001","author":"Ara\u00fajo","key":"R23"},{"key":"R24","series-title":"Dig Liver Dis","first-page":"516","article-title":"Increased liver echogenicity at ultrasound examination reflects degree of steatosis but not of fibrosis in asymptomatic patients with mild\/moderate abnormalities of liver transaminases","volume":"34","author":"Mathiesen","year":"2002"},{"key":"R25","series-title":"Radiol Med (Torino)","first-page":"341","article-title":"Accuracy of ultrasound in the detection of liver fibrosis in chronic viral hepatitis","volume":"110","author":"D'Onofrio","year":"2005"},{"key":"R26","series-title":"Hepatology","first-page":"683","article-title":"Noninvasive assessment of portal hypertension in patients with cirrhosis","volume":"53","author":"Thabut","year":"2011"},{"key":"R27","series-title":"World J Gastroenterol","first-page":"2484","article-title":"Liver fibrosis in chronic viral hepatitis: an ultrasonographic study","volume":"9","author":"Zheng","year":"2002"},{"key":"R28","series-title":"J Radiol","first-page":"1627","article-title":"Doppler ultrasonography evaluation of paraumbilical vein and portal hypertension","volume":"82","author":"de Oliveira","year":"2001"},{"key":"R29","series-title":"Radiology","first-page":"167","article-title":"Ultrasonography in the diagnosis of portal hypertension: diminished response of portal vessels to respiration","volume":"142","author":"Bolondi","year":"1982"},{"key":"R30","series-title":"World J Radiol","first-page":"32","article-title":"Diagnosis of liver cirrhosis with contrast-enhanced ultrasound","volume":"2","author":"Liu","year":"2010"},{"key":"R31","series-title":"J Hepatol","first-page":"269","article-title":"Accuracy and reproducibilty of portal flow measurement by Doppler US","volume":"13","author":"Bolondi","year":"1991"},{"key":"R32","series-title":"J Hepatol","first-page":"298","article-title":"Value of measurement of mean portal flow velocity by Doppler flowmetry in the diagnosis of portal hypertension","volume":"16","author":"Zironi","year":"1992"},{"key":"R33","series-title":"World J Gastroenterol","first-page":"396","article-title":"Hemodynamics in the portal vein evaluated by pulse wave Doppler ultrasonography in patients with chronic hepatitis C treated with interferon","volume":"11","author":"Nakanishi","year":"2005"},{"key":"R34","series-title":"J Ultrasound Med","first-page":"311","article-title":"Value of Doppler sonography in assessing the progression of chronic viral hepatitis and in the diagnosis and grading of cirrhosis","volume":"24","author":"Haktanir","year":"2005"},{"key":"R35","series-title":"Eur J Gastroenterol Hepatol","first-page":"149","article-title":"Diagnostic value of Doppler assessment of the hepatic and portal vessels and ultrasound of the spleen in liver disease","volume":"16","author":"O'Donohue","year":"2004"},{"key":"R36","series-title":"AJR","first-page":"833","article-title":"Abnormalities of Doppler waveform of the hepatic veins in patients with chronic liver disease: correlation with histologic findings","volume":"162","author":"Colli","year":"1994"},{"key":"R37","series-title":"Liver Int","first-page":"1150","article-title":"Noninvasive assessment of liver steatosis, fibrosis and inflammation in chronic hepatitis C virus infection","volume":"25","author":"Schneider","year":"2005"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/86\/2\/article-p273.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/86\/2\/article-p273.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/86\/2\/article-p273.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T18:09:47Z","timestamp":1723054187000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/86\/2\/article-p273.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,1]]},"references-count":37,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.2012.11-0561","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2012,2,1]]}}}