{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:48:00Z","timestamp":1770749280750,"version":"3.50.0"},"reference-count":26,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:p>We evaluated the effectiveness and safety of intralesional meglumine antimoniate (MA) in 24 not submitted to previous treatment patients with cutaneous leishmaniasis (CL) and with contraindication to systemic therapy. Each treatment consisted of one to four intralesional applications of MA at 15-day intervals. Patients' age ranged from 3 to 90 years; fourteen were females. Intralesional treatment in the absence of any relevant toxicity was successful in 20 (83.3%) patients. Three patients required additional treatment with amphotericin B and one required systemic MA. None of the patients developed mucosal lesions when followed up to 60 months. Intralesional MA is an effective and less toxic alternative treatment of patients with CL and contraindication to systemic therapy.<\/jats:p>","DOI":"10.4269\/ajtmh.2012.11-0612","type":"journal-article","created":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T21:56:16Z","timestamp":1343858176000},"page":"257-260","source":"Crossref","is-referenced-by-count":30,"title":["Intralesional Meglumine Antimoniate for Treatment of Cutaneous Leishmaniasis Patients with Contraindication to Systemic Therapy from Rio de Janeiro (2000 to 2006)"],"prefix":"10.4269","volume":"87","author":[{"given":"\u00c9rica de Camargo Ferreira e","family":"Vasconcellos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria In\u00eas Fernandes","family":"Pimentel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando de Oliveira","family":"Schubach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel de Vasconcellos Carvalhaes","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rilza Beatriz","family":"Azeredo-Coutinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1tima da Concei\u00e7\u00e3o","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariza de Matos","family":"Salgueiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Soares","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria de F\u00e1tima","family":"Madeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cibele","family":"Baptista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia Maria","family":"Valete-Rosalino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","first-page":"78","article-title":"Manual de Vigil\u00e2ncia da Leishmaniose Tegumentar Americana","author":"Minist\u00e9rio da Sa\u00fade","year":"2010"},{"key":"R2","series-title":"Trans R Soc Trop Med Hyg","first-page":"339","article-title":"Pentostan (sodium stibogluconate); a 50-year personal reminiscence","volume":"89","author":"Goodwin","year":"1995"},{"key":"R3","series-title":"Lancet","first-page":"1191","article-title":"Leishmaniasis","volume":"354","author":"Herwaldt","year":"1999"},{"key":"R4","series-title":"J Trop Med Hyg","first-page":"133","article-title":"Comparison of meglumine antimoniate and pentamidine for perureian cutaneous leishmaniasis","volume":"72","author":"Andersen","year":"2005"},{"key":"R5","series-title":"Clin Infect Dis","first-page":"1457","article-title":"Safety and efficacy of intravenous sodium stibogluconate in the treatment of leishmaniasis: recent U.S. military experience","volume":"27","author":"Aronson","year":"1998"},{"key":"R6","series-title":"Braz J Med Biol Res","first-page":"297","article-title":"Electrocardiographic changes during low-dose, short-term therapy of cutaneous leishmaniasis with the pentavalent antimonial meglumine","volume":"32","author":"Ribeiro","year":"1999"},{"key":"R7","article-title":"Division of AIDS table for grading the severity of adult and pediatric adverse events","year":"2004"},{"issue":"(III Suppl)","key":"R8","series-title":"Revista da Sociedade Brasileira de Medicina Tropical","first-page":"100","article-title":"O desafio para a realiza\u00e7\u00e3o de ensaios cl\u00ednicos em leishmaniose tegumentar","volume":"39","author":"Romero","year":"2006"},{"key":"R9","series-title":"Rev Soc Bras Med Trop","first-page":"213","article-title":"Retrospective study of 151 patients with cutaneous leishmaniasis treated with meglumine antimoniate","volume":"38","author":"Schubach","year":"2005"},{"key":"R10","series-title":"Rev Soc Bras Med Trop","first-page":"179","article-title":"Human mucocutaneous leishmaniasis in Tres Bracos, Bahia - Brazil. 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