{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:29:31Z","timestamp":1780550971806,"version":"3.54.1"},"reference-count":25,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,6,1]]},"abstract":"<jats:p>For over 60 years, pentavalent antimony (Sb<jats:sup>v<\/jats:sup>) has been the first-line treatment of leishmaniasis. Sickle cell anemia is a disease caused by a defect in red blood cells, which among other things can cause vasooclusive crisis. We report the case of a 6-year-old child with leishmaniasis who during treatment with meglumine antimoniate developed a sickle cell crisis (SCC). No previous reports describing the relationship between antimonial drugs and sickle cell disease were found. Reviews of both the pathophysiology of SCC and the mechanism of action of Sb<jats:sup>v<\/jats:sup> revealed that a common pathway (glutathione) may have resulted in the SCC. ChemoText, a novel database created to predict chemical-protein-disease interactions, was used to perform a more expansive and systematic review that was able to support the association between glutathione, Sb<jats:sup>v<\/jats:sup>, and SCC. Although suggestive evidence to support the hypothesis, additional research at the bench would be needed to prove Sb<jats:sup>v<\/jats:sup> caused the SCC.<\/jats:p>","DOI":"10.4269\/ajtmh.2012.11-0683","type":"journal-article","created":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T20:16:06Z","timestamp":1338840966000},"page":"1057-1061","source":"Crossref","is-referenced-by-count":4,"title":["Possible Links between Sickle Cell Crisis and Pentavalent Antimony"],"prefix":"10.4269","volume":"86","author":[{"given":"Daniel","family":"Garcerant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Rubiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy C.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Craft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Am J Trop Med Hyg","first-page":"738","article-title":"Heterogeneity, geographic distribution, and pathogenicity of serodemes of Leishmania viannia in Colombia","volume":"66","author":"Saravia","year":"2002"},{"key":"R2","series-title":"Lancet Infect Dis","first-page":"581","article-title":"Cutaneous leishmaniasis","volume":"7","author":"Reithinger","year":"2007"},{"key":"R3","series-title":"Drugs","first-page":"1143","article-title":"Sickle cell anaemia: progress in pathogenesis and treatment","volume":"62","author":"Ballas","year":"2002"},{"key":"R4","series-title":"Actual Pediatr (Granada)","first-page":"3","article-title":"Tamizaje para anemia de c\u00e9lulas falciformes en reci\u00e9n nacidos del Hospital Universitario del Valle y del Hospital Mario Correa Renjifo","volume":"7","author":"Jaramillo","year":"1997"},{"key":"R5","series-title":"J Biomed Inform","first-page":"510","article-title":"Mining connections between chemicals, proteins, and diseases extracted from Medline annotations","volume":"43","author":"Baker","year":"2010"},{"key":"R6","series-title":"J Clin Invest","first-page":"1253","article-title":"Spontaneous oxygen radical generation by sickle erythrocytes","volume":"70","author":"Hebbel","year":"1982"},{"key":"R7","series-title":"Blood","first-page":"402","article-title":"Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease","volume":"111","author":"Morris","year":"2008"},{"key":"R8","series-title":"J Natl Med Assoc","first-page":"897","article-title":"Blood antioxidant parameters in sickle cell anemia patients in steady state","volume":"100","author":"Manfredini","year":"2008"},{"key":"R9","series-title":"Am J Physiol Endocrinol Metab","first-page":"E73","article-title":"In vivo rates of erythrocyte glutathione synthesis in adults with sickle cell disease","volume":"291","author":"Reid","year":"2006"},{"key":"R10","series-title":"Br J Haematol","first-page":"112","article-title":"Advanced glycation end-products in sickle cell anaemia","volume":"128","author":"Somjee","year":"2005"},{"key":"R11","series-title":"Acta Biochim Biophys Sin (Shanghai)","first-page":"63","article-title":"Hemin-mediated hemolysis in erythrocytes: effects of ascorbic acid and glutathione","volume":"38","author":"Li","year":"2006"},{"key":"R12","series-title":"Am J Physiol Cell Physiol","first-page":"C867","article-title":"Glutathione protects chemokine-scavenging and antioxidative defense functions in human RBCs","volume":"280","author":"Dumaswala","year":"2001"},{"key":"R13","series-title":"BMC Blood Disord","first-page":"4","article-title":"L-glutamine therapy reduces endothelial adhesion of sickle red blood cells to human umbilical vein endothelial cells","volume":"5","author":"Niihara","year":"2005"},{"key":"R14","series-title":"Eur J Biochem","first-page":"460","article-title":"Trypanothione reductase from Leishmania donovani. 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