{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:41:46Z","timestamp":1792021306203,"version":"4.4.0"},"reference-count":24,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11,7]]},"abstract":"<jats:p>Twenty cases of <jats:italic>Dyphillobothrium pacificum<\/jats:italic> (fish tapeworm) infections were prospectively studied to determine whether this tapeworm is associated with megaloblastic anemia, as commonly reported for <jats:italic>D. latum<\/jats:italic> infections. The most frequent symptoms were fatigue and mild abdominal pain, which were identified in approximately 66.6% of the 18 patients interviewed. Fourteen patients received treatment with niclosamide and all were cured. The other six patients spontaneously eliminated the tapeworms. One patient, who also had chronic diabetes and gastric atrophy, had low vitamin B12 levels and megaloblastic anemia. In all other patients, including three other patients with anemia, baseline vitamin B12 levels were in the reference range and did not significantly change when re-assessed three months later. Unlike <jats:italic>D. latum<\/jats:italic>, infection with <jats:italic>D. pacificum<\/jats:italic> is seldom associated with megaloblastic anemia or vitamin B12 deficit.<\/jats:p>","DOI":"10.4269\/ajtmh.2012.12-0067","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T11:15:22Z","timestamp":1348226122000},"page":"897-901","source":"Crossref","is-referenced-by-count":24,"title":["Diphyllobothrium pacificum Infection is Seldom Associated with Megaloblastic Anemia"],"prefix":"10.4269","volume":"87","author":[{"given":"Juan A.","family":"Jimenez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Gamboa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector H.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"_","family":"_","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Clin Microbiol Rev","first-page":"146","article-title":"Update on the human broad tapeworm (genus Diphyllobothrium), including clinical relevance","volume":"22","author":"Scholz","year":"2009"},{"key":"R2","series-title":"Manual of Clinical Microbiology","first-page":"2222","article-title":"Cestodes","author":"Garcia","year":"2011"},{"key":"R3","series-title":"EuroSurveilli","first-page":"31","article-title":"Current situation of human Diphyllobothrium in Europe","volume":"9","author":"Dupouy-Camet","year":"2004"},{"key":"R4","series-title":"Bol Chil Parasitol","first-page":"22","article-title":"New cases of Diphyllobothrium pacificum (Nybelin, 1931) Margolis, 1956 human infection in northern Chile, probably related with the El Ni\u00f1o phenomenon, 1975\u20132000 [in Spanish]","volume":"56","author":"Sagua","year":"2001"},{"key":"R5","series-title":"Rev Gastroenterol Peru","first-page":"305","article-title":"Spontaneous sedimentation in tube technique (SSTT) for diagnosis of intestinal parasites [in Spanish]","volume":"29","author":"Terashima","year":"2009"},{"key":"R6","series-title":"Am J Trop Med Hyg","first-page":"307","article-title":"Is the human-infecting Diphyllobothrium pacificum a valid species or just a South American population of the holarctic fish broad tapeworm, D. latum?","volume":"75","author":"Sker\u00edkov\u00e1","year":"2006"},{"key":"R7","series-title":"J Clin Microbiol","first-page":"3111","article-title":"Multiplex PCR for differential identification of broad tapeworms (Cestoda: Diphyllobothrium) infecting humans","volume":"48","author":"Wicht","year":"2010"},{"key":"R8","series-title":"Ann Intern Med","first-page":"550","article-title":"Niclosamide therapy for tapeworm infections","volume":"102","author":"Pearson","year":"1985"},{"key":"R9","series-title":"Tropenmed Parasitol","first-page":"5","article-title":"Single dose treatment with praziquantel (Cesol R, EmBay 8440) of human cestodiasis caused by Diphyllobothrium pacificum","volume":"33","author":"Lumbreras","year":"1982"},{"key":"R10","series-title":"BMJ","first-page":"1028","article-title":"Pathogenesis of the tapeworm anaemia","volume":"2","author":"Anonymous","year":"1976"},{"key":"R11","series-title":"Ann Hematol","first-page":"487","article-title":"Case of megaloblastic anemia caused by intestinal taeniasis","volume":"83","author":"Vuylsteke","year":"2004"},{"key":"R12","series-title":"Rev Med Chil","first-page":"700","article-title":"Severe megaloblastic anemia due to Diphyllobotrium latum. First case identified in Chile [in Spanish]","volume":"102","author":"Osorio","year":"1974"},{"key":"R13","series-title":"Am J Clin Nutr","first-page":"606","article-title":"Serum vitamin B12 levels and incidence of tapeworm anemia in a population heavily infected with Diphyllobothrium latum","volume":"9","author":"Nyberg","year":"1961"},{"key":"R14","series-title":"Clin Med Res","first-page":"236","article-title":"Megaloblastic anemia and other causes of macrocytosis","volume":"4","author":"Aslinia","year":"2006"},{"key":"R15","series-title":"Bol Chil Parasitol","first-page":"26","article-title":"Diphyllobothrium pacificum (Nybelin, 1931) Margolis, 1956 en Canis familiaris de la ciudad de Chincha, Per\u00fa","volume":"56","author":"Cabrera","year":"2001"},{"key":"R16","series-title":"Paleopathology Newsletter","first-page":"11","article-title":"Eggs of Diphyllobothrium pacificum in precolumbian human coprolites","volume":"41","author":"Araujo","year":"1983"},{"issue":"(Suppl 1)","key":"R17","series-title":"Mem Inst Oswaldo Cruz","first-page":"191","article-title":"Diagnosing ancient diphyllobothriasis from Chinchorro mummies","volume":"98","author":"Reinhard","year":"2003"},{"key":"R18","series-title":"Mem Inst Oswaldo Cruz","first-page":"175","article-title":"The finding of eggs of Diphyllobothrium in human coprolites (4,100\u20131,950 bc) from northern Chile","volume":"79","author":"Ferreira","year":"1984"},{"key":"R19","series-title":"Manual de Procedimientos de Laboratorio en Tecnicas Basicas de Hematologia","first-page":"40","author":"Mu\u00f1oz","year":"2005"},{"key":"R20","article-title":"Vitamina B12. Elecsys\u00ae Sistemas 2010\/Modular Analytics E170","author":"Anonymous","year":"2001"},{"key":"R21","series-title":"Diagnostico (Peru)","first-page":"161","article-title":"Diphyllobothrium pacificum en ni\u00f1os del Peru","volume":"41","author":"Medina","year":"2002"},{"key":"R22","series-title":"Medical Microbiology","article-title":"Chapter 89. Cestodes","author":"Heyneman","year":"1996"},{"key":"R23","series-title":"Proc Nutr Soc","first-page":"8","article-title":"Diphyllobothrium latum and human nutrition, with particular reference to vitamin B12 deficiency","volume":"22","author":"Nyberg","year":"1963"},{"key":"R24","series-title":"Rev Med Chil","first-page":"1171","article-title":"Megaloblastic anemia induced by Diphyllobothrium latum infection","volume":"114","author":"Donoso-Scroppo","year":"1986"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/87\/5\/article-p897.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/87\/5\/article-p897.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/87\/5\/article-p897.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T13:16:01Z","timestamp":1723036561000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/87\/5\/article-p897.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,7]]},"references-count":24,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.2012.12-0067","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,7]]}}}