{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T21:38:12Z","timestamp":1762033092757},"reference-count":31,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1,9]]},"abstract":"<jats:p>We evaluated whether coadministration of the yellow fever (YF) virus vaccine with human immunoglobulin (Ig) that contained YF virus-neutralizing antibodies would reduce post-vaccination viremia without compromising immunogenicity and thus, potentially mitigate YF vaccine-associated adverse events. We randomized 80 participants to receive either YF vaccine and Ig or YF vaccine and saline placebo. Participants were followed for 91 days for safety and assessments of viremia and immunogenicity. There were no differences found between the two groups in the proportion of vaccinated participants who developed viremia, seroconversion, cluster of differentiation (CD)-8<jats:sup>+<\/jats:sup> and CD4<jats:sup>+<\/jats:sup> T-cell responses, and cytokine responses. These results argue against one putative explanation for the increased reporting of YF vaccine side effects in recent years (i.e., a change in travel clinic practice after 1996 when hepatitis A prophylaxis with vaccine replaced routine use of pre-travel Ig, thus potentially removing an incidental YF vaccine-attenuating effect of anti-YF virus antibodies present in Ig) (ClinicalTrials.gov identifier: NCT00254826).<\/jats:p>","DOI":"10.4269\/ajtmh.2012.12-0179","type":"journal-article","created":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T15:51:11Z","timestamp":1354636271000},"page":"172-177","source":"Crossref","is-referenced-by-count":26,"title":["A Randomized, Double-Blind, Controlled Trial of the 17D Yellow Fever Virus Vaccine Given in Combination with Immune Globulin or Placebo: Comparative Viremia and Immunogenicity"],"prefix":"10.4269","volume":"88","author":[{"given":"Srilatha","family":"Edupuganti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel B.","family":"Eidex","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Keyserling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rama S.","family":"Akondy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Lanciotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Orenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"del 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J.","family":"Mulligan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"The Yellow Book","article-title":"Health information for international travel","author":"Centers for Disease Control and Prevention","year":"2012"},{"key":"R2","series-title":"Curr Opin Immunol","first-page":"308","article-title":"Yellow fever vaccine\u2014how does it work and why do rare cases of serious adverse events take place?","volume":"21","author":"Barrett","year":"2009"},{"key":"R3","series-title":"Lancet","first-page":"98","article-title":"Fever and multiorgan failure associated with 17D-204 yellow fever: a report of four cases","volume":"358","author":"Martin","year":"2001"},{"key":"R4","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"989","article-title":"Adverse events associated with 17D-derived yellow fever vaccination\u2014United States, 2001\u20132002","volume":"51","author":"Centers for 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