{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:34:53Z","timestamp":1793064893806,"version":"4.5.0"},"reference-count":31,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10,3]]},"abstract":"<jats:p>Paracoccidioidomycosis (PCM), the most important human systemic mycosis in Latin America, is known to be caused by at least four different phylogenetic lineages within the <jats:italic>Paracoccidioides brasiliensis<\/jats:italic> complex, including S1, PS2, PS3, and Pb01-like group. Herein, we describe two cases of PCM in patients native from the Amazon region. The disease was originally thought to have been caused by <jats:italic>P. brasiliensis<\/jats:italic>. Despite the severity of the cases, sera from the patients were negative in immunodiffusion tests using the standard exoantigen from <jats:italic>P. brasiliensis<\/jats:italic> B-339. However, a positive response was recorded with an autologous preparation of <jats:italic>Paracoccidioides lutzii<\/jats:italic> exoantigen. A phylogenetic approach based on the gp43 and ARF loci revealed high similarity between our clinical isolates and the Pb01-like group. The occurrence of PCM caused by <jats:italic>P. lutzii<\/jats:italic> in the Brazilian Amazon (Par\u00e1 State) was thus proven. The incidence of PCM caused by <jats:italic>P. lutzii<\/jats:italic> may be underestimated in northern Brazil.<\/jats:p>","DOI":"10.4269\/ajtmh.2012.12-0340","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T15:15:22Z","timestamp":1348240522000},"page":"710-714","source":"Crossref","is-referenced-by-count":47,"title":["Occurrence of Paracoccidioides lutzii in the Amazon Region: Description of Two Cases"],"prefix":"10.4269","volume":"87","author":[{"given":"Silvia Helena","family":"Marques-da-Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson","family":"Messias Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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