{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T03:12:26Z","timestamp":1770520346337,"version":"3.49.0"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,15]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>This retrospective and single-center study in Reunion Island (Indian Ocean) assessed frequency, mortality, causative pathogens of severe necrotizing skin, and necrotizing skin and soft tissue infections (NSSTIs) admitted in intensive care unit (ICU). Sixty-seven consecutive patients were included from January 2012 to December 2018. Necrotizing skin and soft tissue infection represented 1.06% of total ICU admissions. We estimate the incidence of NSSTI requiring ICU at 1.21\/100,000 person\/years in Reunion Island. Twenty (30%) patients were receiving nonsteroidal anti-inflammatory drugs (NSAIDs) prior to admission in ICU and 40 (60%) were diagnosed patients with diabetes. Sites of infection were the lower limb in 52 (78%) patients, upper limb in 4 (6%), and perineum in 10 (15%). The surgical treatment was debridement for 40 patients, whereas 11 patients required an amputation. The most commonly isolated microorganisms were Streptococci (42%) and Gram-negative bacteria (22%).The mortality rate was 25.4%. NSAIDs did not influence mortality when interrupted upon admission to ICU.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0009","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T11:45:17Z","timestamp":1626695117000},"page":"596-599","source":"Crossref","is-referenced-by-count":6,"title":["Necrotizing Skin and Soft Tissue Infections Admitted to Intensive Care Unit in Reunion Island: A Retrospective Cohort Study"],"prefix":"10.4269","volume":"105","author":[{"given":"David","family":"Vandroux","sequence":"first","affiliation":[{"name":"1UMR 1094 Neuro\u00e9pid\u00e9miologie Tropicale, University of Limoges, Limoges, France;"},{"name":"2Cardio-Surgical Intensive Care Unit, CHU Limoges, Limoges, France;"},{"name":"3Ren\u00e9 Labusqui\u00e8re Centre of Tropical Medicine, University of Bordeaux, Bordeaux, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexia Mubuanga","family":"Nkusu","sequence":"additional","affiliation":[{"name":"1UMR 1094 Neuro\u00e9pid\u00e9miologie Tropicale, University of Limoges, Limoges, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard-Alex","family":"Gauzere","sequence":"additional","affiliation":[{"name":"3Ren\u00e9 Labusqui\u00e8re Centre of Tropical Medicine, University of Bordeaux, Bordeaux, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Martinet","sequence":"additional","affiliation":[{"name":"4Intensive Care Unit, F\u00e9lix Guyon Hospital, University Teaching Hospital of La R\u00e9union, Reunion Island, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/3\/article-p596.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/105\/3\/article-p596.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T13:02:07Z","timestamp":1632402127000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/3\/article-p596.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,15]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0009","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,15]]}}}