{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:34:48Z","timestamp":1792211688017,"version":"4.4.0"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,15]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>In low-endemicity settings, current tools for the diagnosis and surveillance of schistosomiasis are often inaccurate in detecting true infection. We assessed the accuracy of an up-converting phosphor lateral flow circulating anodic antigen (UCP-LF CAA) test and a point-of-care circulating cathodic antigen (POC-CCA) urine cassette test for the diagnosis of <jats:italic>Schistosoma mansoni<\/jats:italic>. Our study was conducted in eight schools of western C\u00f4te d\u2019Ivoire. Fifty children, aged 9\u201312 years, were enrolled per school. From each child, a single urine specimen and two stool specimens were collected over consecutive days for diagnostic work-up. Urine samples were subjected to UCP-LF CAA and POC-CCA tests. From each stool sample, triplicate Kato-Katz thick smears were examined. Overall, 378 children had complete data records. The prevalence of <jats:italic>S. mansoni<\/jats:italic>, as assessed by six Kato-Katz thick smears, was 4.0%. The UCP-LF CAA and POC-CCA tests revealed <jats:italic>S. mansoni<\/jats:italic> prevalence of 25.4% and 30.7%, respectively, when considering trace results as positive, and prevalence of 23.3% and 10.9% when considering trace results as negative. In the latter case, based on a composite \u201cgold\u201d standard, the sensitivity of UCP-LF CAA (80.7%) was considerably higher than that of POC-CCA (37.6%) and six Kato-Katz thick smears (13.8%). The negative predictive value of UCP-LF CAA, POC-CCA, and six Kato-Katz thick smears was 92.8%, 79.8%, and 74.1%, respectively. Our results confirm that UCP-LF CAA is more accurate than Kato-Katz and POC-CCA for the diagnosis of <jats:italic>S. mansoni<\/jats:italic> in low-endemicity settings.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0031","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T11:45:16Z","timestamp":1626695116000},"page":"677-683","source":"Crossref","is-referenced-by-count":19,"title":["Accuracy of Two Circulating Antigen Tests for the Diagnosis and Surveillance of Schistosoma mansoni Infection in Low-Endemicity Settings of C\u00f4te d\u2019Ivoire"],"prefix":"10.4269","volume":"105","author":[{"given":"Rufin K.","family":"Assar\u00e9","sequence":"first","affiliation":[{"name":"1Unit\u00e9 de Formation et de Recherche Biosciences, Universit\u00e9 F\u00e9lix Houphou\u00ebt-Boigny, Abidjan, C\u00f4te d\u2019Ivoire;"},{"name":"2Centre Suisse de Recherches Scientifiques en C\u00f4te d\u2019Ivoire, Abidjan, C\u00f4te d\u2019Ivoire;"},{"name":"3Swiss Tropical and Public Health Institute, Basel, Switzerland;"},{"name":"4University of Basel, Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu I.","family":"Tra-Bi","sequence":"additional","affiliation":[{"name":"1Unit\u00e9 de Formation et de Recherche Biosciences, Universit\u00e9 F\u00e9lix Houphou\u00ebt-Boigny, Abidjan, C\u00f4te d\u2019Ivoire;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean T.","family":"Coulibaly","sequence":"additional","affiliation":[{"name":"1Unit\u00e9 de Formation et de Recherche Biosciences, Universit\u00e9 F\u00e9lix Houphou\u00ebt-Boigny, Abidjan, C\u00f4te d\u2019Ivoire;"},{"name":"2Centre Suisse de Recherches Scientifiques en C\u00f4te d\u2019Ivoire, Abidjan, C\u00f4te d\u2019Ivoire;"},{"name":"3Swiss Tropical and Public Health Institute, Basel, Switzerland;"},{"name":"4University of Basel, Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul L. A. M.","family":"Corstjens","sequence":"additional","affiliation":[{"name":"5Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamadou","family":"Ouattara","sequence":"additional","affiliation":[{"name":"1Unit\u00e9 de Formation et de Recherche Biosciences, Universit\u00e9 F\u00e9lix Houphou\u00ebt-Boigny, Abidjan, C\u00f4te d\u2019Ivoire;"},{"name":"2Centre Suisse de Recherches Scientifiques en C\u00f4te d\u2019Ivoire, Abidjan, C\u00f4te d\u2019Ivoire;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline","family":"H\u00fcrlimann","sequence":"additional","affiliation":[{"name":"3Swiss Tropical and Public Health Institute, Basel, Switzerland;"},{"name":"4University of Basel, Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govert J.","family":"van Dam","sequence":"additional","affiliation":[{"name":"6Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrg","family":"Utzinger","sequence":"additional","affiliation":[{"name":"3Swiss Tropical and Public Health Institute, Basel, Switzerland;"},{"name":"4University of Basel, Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli\u00e9zer K.","family":"N\u2019Goran","sequence":"additional","affiliation":[{"name":"1Unit\u00e9 de Formation et de Recherche Biosciences, Universit\u00e9 F\u00e9lix Houphou\u00ebt-Boigny, Abidjan, C\u00f4te d\u2019Ivoire;"},{"name":"2Centre Suisse de Recherches Scientifiques en C\u00f4te d\u2019Ivoire, Abidjan, C\u00f4te d\u2019Ivoire;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/3\/article-p677.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/105\/3\/article-p677.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T13:01:52Z","timestamp":1632402112000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/3\/article-p677.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,15]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0031","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,15]]}}}