{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T17:46:56Z","timestamp":1757699216368},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,2]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p>A decrease in the clinical efficacy of a 3-day artesunate\u2013mefloquine combination treatment was reported in the areas of multidrug-resistant <jats:italic>Plasmodium falciparum<\/jats:italic> along the Thailand\u2013Myanmar border. The current study investigated the possible contribution of genetic polymorphisms of the three major genes encoding drug efflux transporters, <jats:italic>ABCB1<\/jats:italic>, <jats:italic>ABCG2<\/jats:italic>, and <jats:italic>ABCC1<\/jats:italic>, to responses to the aforementioned treatment in 91 patients with acute uncomplicated falciparum malaria residing along the Thailand\u2013Myanmar border. Patients carrying homozygous mutant genotype <jats:italic>ABCB1 c.1236C&gt;T<\/jats:italic> (TT) were found to have a three-times higher chance of successful treatment with this combination compared with other genotypes (CC and CT). Furthermore, whole blood mefloquine concentrations in these patients with the TT genotype were significantly lower than those of patients carrying the CC genotype. Patients with heterozygous mutant genotype (CT), however, were three-times more likely to experience treatment failure. No significant association was found with the <jats:italic>ABCG2<\/jats:italic> and <jats:italic>ABCC1<\/jats:italic> gene polymorphisms. The results suggest that <jats:italic>ABCB1 c.1236C&gt;T<\/jats:italic> polymorphisms could be useful genetic markers for predicting responses to the 3-day artesunate\u2013mefloquine treatment; however, studies using larger sample sizes in different malaria-endemic areas are necessary to confirm this finding. This study highlights the impact of pharmacogenetic factors on antimalarial treatment responses and the basis for the application of control policies in various malaria-endemic areas.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0047","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T14:30:38Z","timestamp":1620052238000},"page":"2152-2158","source":"Crossref","is-referenced-by-count":4,"title":["Association between ABCB1 Polymorphisms and Artesunate\u2013Mefloquine Treatment Responses of Patients with Falciparum Malaria on the Thailand\u2013Myanmar Border"],"prefix":"10.4269","volume":"104","author":[{"given":"Kanyarat","family":"Boonprasert","sequence":"first","affiliation":[{"name":"1Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Pathum Thani, Thailand;"},{"name":"2Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Pathum Thani, Thailand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanthawat","family":"Kosa","sequence":"additional","affiliation":[{"name":"1Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Pathum Thani, Thailand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poonuch","family":"Muhamad","sequence":"additional","affiliation":[{"name":"3Drug Discovery and Development Center, Thammasat University (Rangsit Campus), Pathum Thani, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anurak","family":"Cheoymang","sequence":"additional","affiliation":[{"name":"1Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Pathum Thani, Thailand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kesara","family":"Na-Bangchang","sequence":"additional","affiliation":[{"name":"1Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Pathum Thani, Thailand;"},{"name":"2Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Pathum Thani, Thailand;"},{"name":"3Drug Discovery and Development Center, Thammasat University (Rangsit Campus), Pathum Thani, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/104\/6\/article-p2152.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/104\/6\/article-p2152.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T16:40:42Z","timestamp":1622652042000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/104\/6\/article-p2152.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,2]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0047","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,2]]}}}