{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:34:10Z","timestamp":1788348850175,"version":"build-2803163510"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,15]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>In 2005, artemether-lumefantrine (AL), an artemisinin-based combination therapy, was introduced as the first-line treatment of uncomplicated <jats:italic>Plasmodium falciparum<\/jats:italic> malaria in Benin. Per World Health Organization recommendations to monitor the efficacy of antimalarial treatment, we conducted a therapeutic efficacy study with AL for uncomplicated <jats:italic>P. falciparum<\/jats:italic> malaria in Bohicon and Kandi, Benin, from 2018 to 2019. Febrile patients aged 6 to 59 months with confirmed <jats:italic>P. falciparum<\/jats:italic> monoinfection received supervised doses of AL for 3 days. We monitored patients clinically and parasitologically on days 1, 2, 3, 7, 14, 21, and 28. A molecular analysis to detect mutations in the <jats:italic>P. falciparum <\/jats:italic>Kelch propeller gene (<jats:italic>Pfk13<\/jats:italic>) gene was carried out on day 0 samples. A total of 205 patients were included in the study. In Bohicon, the uncorrected adequate clinical and parasitological response (ACPR) proportion was 91.3% (95% confidence interval [CI]: 84.6\u201395.8%), whereas in Kandi this proportion was 96.7% (95% CI: 90.6\u201399.3%). Genotype-corrected ACPR proportions were 96.3% (95% CI: 90.9\u201399.0%) and 96.7% (95% CI: 90.6\u201399.3%) in Bohicon and Kandi, respectively. On day 3, 100% of patients in Bohicon and 98.9% of patients in Kandi had undetectable parasitemia. The C580Y mutation in the <jats:italic>Pfk13<\/jats:italic> gene was not observed. AL remains effective for <jats:italic>P. falciparum<\/jats:italic> malaria in these two sites in Benin. Monitoring antimalarial efficacy and prevalence of molecular-resistance markers in Benin should be continued to allow for early detection of antimalarial resistance and to guide treatment policies.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0086","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T20:56:34Z","timestamp":1626123394000},"page":"670-676","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy of Artemether-Lumefantrine for the Treatment of Plasmodium falciparum Malaria in Bohicon and Kandi, Republic of Benin, 2018\u20132019"],"prefix":"10.4269","volume":"105","author":[{"given":"Augustin","family":"Kpemasse","sequence":"first","affiliation":[{"name":"1Laboratory Service and Chemo Sensitivity, Benin National Malaria Control Program, Cotonou, Benin;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fortune","family":"Dagnon","sequence":"additional","affiliation":[{"name":"2U.S. President\u2019s Malaria Initiative, U.S. Agency for International Development Benin Office, Cotonou, Benin;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramani","family":"Saliou","sequence":"additional","affiliation":[{"name":"1Laboratory Service and Chemo Sensitivity, Benin National Malaria Control Program, Cotonou, Benin;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis Sacca","family":"Yarou Maye","sequence":"additional","affiliation":[{"name":"1Laboratory Service and Chemo Sensitivity, Benin National Malaria Control Program, Cotonou, Benin;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyriaque Dossou","family":"Affoukou","sequence":"additional","affiliation":[{"name":"1Laboratory Service and Chemo Sensitivity, Benin National Malaria Control Program, Cotonou, Benin;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alassane","family":"Zoulkaneri","sequence":"additional","affiliation":[{"name":"3Kandi Health Center, Alibori Department, Benin Ministry of Health, Kandi, Benin;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blaise","family":"Gu\u00e9zo-M\u00e9vo","sequence":"additional","affiliation":[{"name":"4Bohicon Health Center, Zou Department, Benin Ministry of Health, Bohicon, Benin;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah F.","family":"Moriarty","sequence":"additional","affiliation":[{"name":"5Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, and the U.S. President\u2019s Malaria Initiative, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaye D.","family":"Ndiaye","sequence":"additional","affiliation":[{"name":"6Molecular Biology and Genomics Laboratory, Aristide Hospital DANTEC, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamane Nassirou","family":"Garba","sequence":"additional","affiliation":[{"name":"6Molecular Biology and Genomics Laboratory, Aristide Hospital DANTEC, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awa Bineta","family":"Deme","sequence":"additional","affiliation":[{"name":"6Molecular Biology and Genomics Laboratory, Aristide Hospital DANTEC, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daouda","family":"Ndiaye","sequence":"additional","affiliation":[{"name":"6Molecular Biology and Genomics Laboratory, Aristide Hospital DANTEC, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore Ogouyemi","family":"Hounto","sequence":"additional","affiliation":[{"name":"1Laboratory Service and Chemo Sensitivity, Benin National Malaria Control Program, Cotonou, Benin;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/3\/article-p670.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/105\/3\/article-p670.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T13:01:54Z","timestamp":1632402114000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/3\/article-p670.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,15]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0086","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,15]]}}}