{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:46:43Z","timestamp":1790729203274,"version":"4.1.0"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,6]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Lower yield of available diagnostic tests for tuberculous meningitis (TBM) frequently causes delay in diagnosis. Recently, 18F-fluorodeoxyglucose positron emission tomography (FDG PET) has been used in infectious disorders such as pulmonary tuberculosis; however, it is rarely used in TBM. This study was aimed to ascertain the role of FDG PET in the diagnosis and determination of the extent of disease and prognosis in patients with TBM. After excluding unsuitable patients, 25 patients were subjected to whole-body PET\u2013computed tomography (CT) image acquisition along with separate brain protocol with an integrated PET-CT device. FDG PET was found to be abnormal in 92% patients. Extracranial FDG uptake was observed in 80% patients. Most common extracranial site of involvement was lymph nodes (60%), followed by lung (56%), vertebral body (8%), genitourinary organs (8%), and spleen (4%). FDG PET observed extracranial involvement had 80% sensitivity and 20% specificity in detecting definite TBM cases. In conclusion, FDG PET may be a useful test in TBM evaluation.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0102","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T11:45:15Z","timestamp":1626695115000},"page":"1038-1041","source":"Crossref","is-referenced-by-count":5,"title":["18FDG-Positron Emission Tomography in patients with Tuberculous Meningitis: A Prospective Evaluation"],"prefix":"10.4269","volume":"105","author":[{"given":"Harish","family":"Nigam","sequence":"first","affiliation":[{"name":"1Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Gambhir","sequence":"additional","affiliation":[{"name":"2Department of Nuclear Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Pandey","sequence":"additional","affiliation":[{"name":"1Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra Kumar","family":"Garg","sequence":"additional","affiliation":[{"name":"1Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Verma","sequence":"additional","affiliation":[{"name":"1Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vimal Kumar","family":"Paliwal","sequence":"additional","affiliation":[{"name":"3Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hardeep Singh","family":"Malhotra","sequence":"additional","affiliation":[{"name":"1Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"1Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Kumar","sequence":"additional","affiliation":[{"name":"1Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Rizvi","sequence":"additional","affiliation":[{"name":"1Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amita","family":"Jain","sequence":"additional","affiliation":[{"name":"4Department of Microbiology, King George Medical University, Lucknow, Uttar Pradesh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neera","family":"Kohli","sequence":"additional","affiliation":[{"name":"5Department of Radiodiagnosis, King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek Kumar","family":"Saini","sequence":"additional","affiliation":[{"name":"2Department of Nuclear Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Uniyal","sequence":"additional","affiliation":[{"name":"1Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/4\/article-p1038.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/105\/4\/article-p1038.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T18:41:03Z","timestamp":1633545663000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/4\/article-p1038.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,6]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0102","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,6]]}}}