{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:23:41Z","timestamp":1791386621594,"version":"4.3.3"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,7]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p>Granulomatous amebic encephalitis (GAE) caused by <jats:italic>Acanthamoeba<\/jats:italic> is a rare infection with central nervous system (CNS) involvement usually with fatal consequences. Currently, information regarding GAE in children is scarce and is limited only to case reports and case series. A 13-year-old immunocompetent male patient with a 6-month history of progressive and intermittent headaches presented to our institution. One week before hospital admission, the patient showed signs of CNS involvement. Magnetic resonance imaging revealed multiple lesions with supra- and infratentorial cerebral abscesses. An empiric treatment with combined antibiotics was given, but the patient died after 20 days of hospital stay. A postmortem diagnosis confirmed GAE. Although it is a rare disease in pediatric patients, GAE should be considered in children with a chronic history of fever, headache, and vomiting with CNS involvement.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0129","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T15:36:55Z","timestamp":1620661015000},"page":"167-170","source":"Crossref","is-referenced-by-count":9,"title":["Case Report: Granulomatous Amebic Encephalitis due to Acanthamoeba spp. in an Immunocompetent Pediatric Patient"],"prefix":"10.4269","volume":"105","author":[{"given":"Denisse Vaquera","family":"Aparicio","sequence":"first","affiliation":[{"name":"1Department of Pediatrics\/Infectious Diseases Service, Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez,\u201d Universidad Autonoma de Nuevo Leon, Monterrey, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Iv\u00e1n Castillo","family":"Bejarano","sequence":"additional","affiliation":[{"name":"1Department of Pediatrics\/Infectious Diseases Service, Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez,\u201d Universidad Autonoma de Nuevo Leon, Monterrey, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abiel Mascare\u00f1as","family":"de los Santos","sequence":"additional","affiliation":[{"name":"1Department of Pediatrics\/Infectious Diseases Service, Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez,\u201d Universidad Autonoma de Nuevo Leon, Monterrey, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Ram\u00edrez-Cortinas","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez,\u201d Universidad Autonoma de Nuevo Le\u00f3n, Monterrey, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"de la O Cavazos","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez,\u201d Universidad Autonoma de Nuevo Le\u00f3n, Monterrey, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/1\/article-p167.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/105\/1\/article-p167.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:40:57Z","timestamp":1628728857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/1\/article-p167.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,7]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0129","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,7]]}}}