{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T07:35:25Z","timestamp":1771054525551,"version":"3.50.1"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,2]]},"abstract":"<jats:title>Abstract.<\/jats:title><jats:p><jats:italic>Fasciola hepatica<\/jats:italic> is highly prevalent in the highlands of Peru. School-age children have the greatest risk of infection. Mass treatment of at-risk populations has been proposed to control the infection and prevent complications. However, the decreasing effectiveness of triclabendazole raises concerns regarding this strategy. Previous studies reported aggregation of <jats:italic>Fasciola<\/jats:italic> infection among family members. This study aimed to determine the risk of fascioliasis among household members living with <jats:italic>Fasciola<\/jats:italic>-infected children identified through school-based testing. We conducted a cross-sectional study including adult members of households where children with and without fascioliasis were identified. Demographic, epidemiological, and socioeconomic information was collected. One blood sample was drawn to test for <jats:italic>Fasciola<\/jats:italic> antibodies, and three stool samples were collected for microscopy for <jats:italic>Fasciola<\/jats:italic> ova. We tested 326 adults from 213 households. Of these adult subjects, chronic fascioliasis (24 of 326, 7.4%) was the most common helminth infection. Thirty-nine subjects (12.7%) tested positive for <jats:italic>Fasciola<\/jats:italic> antibodies. Combining microscopy and serum antibody tests, 13.2% (43 of 326) had evidence of <jats:italic>Fasciola<\/jats:italic> infection. One third (104 of 326, 31.9%) of the participants lived with at least one child infected with <jats:italic>Fasciola hepatica<\/jats:italic>. Adults with fascioliasis were four times more likely to live with an infected child. Poverty and diet were associated with increased risk of <jats:italic>Fasciola<\/jats:italic> infection. Adults with fascioliasis were significantly more likely to live with <jats:italic>Fasciola<\/jats:italic>-infected children.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0131","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T14:29:35Z","timestamp":1620052175000},"page":"2069-2073","source":"Crossref","is-referenced-by-count":5,"title":["Fasciola hepatica Infection Risk for Adult Household Members Living with Children with Fascioliasis in Cusco, Peru"],"prefix":"10.4269","volume":"104","author":[{"given":"Maria A.","family":"Caravedo","sequence":"first","affiliation":[{"name":"1Division of Infectious Disease, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Ramirez","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, Hospital Nacional Adolfo Guevara Velasco ESSALUD, Cusco, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria L.","family":"Morales","sequence":"additional","affiliation":[{"name":"3Cusco Branch, Tropical Medicine Institute, Universidad Peruana Cayetano Heredia, Cusco, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Lopez","sequence":"additional","affiliation":[{"name":"3Cusco Branch, Tropical Medicine Institute, Universidad Peruana Cayetano Heredia, Cusco, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire E.","family":"Janes","sequence":"additional","affiliation":[{"name":"4School of Medicine, University of Texas Medical Branch, Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany A.","family":"Bunag","sequence":"additional","affiliation":[{"name":"4School of Medicine, University of Texas Medical Branch, Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie L.","family":"Mixon","sequence":"additional","affiliation":[{"name":"4School of Medicine, University of Texas Medical Branch, Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Clinton","family":"White","sequence":"additional","affiliation":[{"name":"1Division of Infectious Disease, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas;"},{"name":"3Cusco Branch, Tropical Medicine Institute, Universidad Peruana Cayetano Heredia, Cusco, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda B.","family":"Tanabe","sequence":"additional","affiliation":[{"name":"1Division of Infectious Disease, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel M.","family":"Cabada","sequence":"additional","affiliation":[{"name":"1Division of Infectious Disease, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas;"},{"name":"3Cusco Branch, Tropical Medicine Institute, Universidad Peruana Cayetano Heredia, Cusco, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/104\/6\/article-p2069.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/104\/6\/article-p2069.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:40:56Z","timestamp":1628728856000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/104\/6\/article-p2069.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,2]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0131","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,2]]}}}