{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:57:43Z","timestamp":1787162263302,"version":"build-2736575974"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,11]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>The risk of coronavirus disease 2019 (COVID-19) and dengue coinfection is increased in tropical countries; however, the extrapulmonary clinical manifestations have not been fully characterized. We report a 42-year-old woman whose clinical manifestations began with fever, diarrhea, headache, chest pain, myalgia, odynophagia, and arthralgia. Despite mild respiratory symptoms and normal chest computed tomography scan results, she was diagnosed with real-time reverse-transcription polymerase chain reaction (RT-PCR)-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Because she had erythema and petechiae with a decreased platelet count, the dengue NS1 antigen and anti-dengue IgM\/IgG test were performed, and the Centers for Disease Control and Prevention RT-PCR assay detected the dengue virus serotype 1 infection. Additionally, increased liver enzyme serum levels were found in the patient, who later developed hepatomegaly. Hence, the mechanism of hepatic pathology associated with SARS-CoV-2 and dengue coinfection needs further research.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0177","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T12:26:53Z","timestamp":1624883213000},"page":"363-367","source":"Crossref","is-referenced-by-count":12,"title":["Case Report: Extrapulmonary Manifestations of COVID-19 and Dengue Coinfection"],"prefix":"10.4269","volume":"105","author":[{"given":"Jos\u00e9 Manuel","family":"Reyes-Ruiz","sequence":"first","affiliation":[{"name":"1Unidad M\u00e9dica de Alta Especialidad, Hospital de Especialidades No. 14, Centro M\u00e9dico Nacional \u201cAdolfo Ruiz Cortines\u201d, Instituto Mexicano del Seguro Social, Veracruz, Veracruz, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Campuzano-Vences","sequence":"additional","affiliation":[{"name":"2Laboratorio de Biolog\u00eda Molecular, Laboratorio Estatal de Salud P\u00fablica del Estado de M\u00e9xico, State of Mexico, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Fidel","family":"Osuna-Ramos","sequence":"additional","affiliation":[{"name":"3Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies (CINVESTAV-IPN), Mexico City, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Adri\u00e1n","family":"De Jes\u00fas-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"3Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies (CINVESTAV-IPN), Mexico City, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J.","family":"P\u00e9rez-M\u00e9ndez","sequence":"additional","affiliation":[{"name":"2Laboratorio de Biolog\u00eda Molecular, Laboratorio Estatal de Salud P\u00fablica del Estado de M\u00e9xico, State of Mexico, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crescencio","family":"Gonz\u00e1lez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"4Hospital General Miguel Hidalgo y Costilla Bicentenario, State of Mexico, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Noe","family":"Farfan-Morales","sequence":"additional","affiliation":[{"name":"3Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies (CINVESTAV-IPN), Mexico City, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Rivas-Tovar","sequence":"additional","affiliation":[{"name":"4Hospital General Miguel Hidalgo y Costilla Bicentenario, State of Mexico, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"D\u00e1vila-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"2Laboratorio de Biolog\u00eda Molecular, Laboratorio Estatal de Salud P\u00fablica del Estado de M\u00e9xico, State of Mexico, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Mar\u00eda del \u00c1ngel","sequence":"additional","affiliation":[{"name":"3Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies (CINVESTAV-IPN), Mexico City, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aar\u00f3n P.","family":"Guti\u00e9rrez-Gardu\u00f1o","sequence":"additional","affiliation":[{"name":"5Departamento de Epidemiolog\u00eda, Jurisdicci\u00f3n Sanitaria Tlanepantla ISEM, State of Mexico, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Villegas-del \u00c1ngel","sequence":"additional","affiliation":[{"name":"6Centro M\u00e9dico ABC, Mexico City, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Z\u00e1rate-Segura","sequence":"additional","affiliation":[{"name":"7Laboratorio de Medicina Traslacional, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Bastida-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"2Laboratorio de Biolog\u00eda Molecular, Laboratorio Estatal de Salud P\u00fablica del Estado de M\u00e9xico, State of Mexico, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/2\/article-p363.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/105\/2\/article-p363.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T14:17:35Z","timestamp":1628864255000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/2\/article-p363.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,11]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0177","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,11]]}}}