{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:07:41Z","timestamp":1758402461727},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,5]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Rift Valley fever phlebovirus (RVFV) is a mosquito-transmitted phlebovirus (Family: <jats:italic>Phenuiviridae<\/jats:italic>, Order: <jats:italic>Bunyavirales<\/jats:italic>) causing severe neonatal mortality and abortion primarily in domestic ruminants. The susceptibility of young domestic swine to RVFV and this species\u2019 role in geographic expansion and establishment of viral endemicity is unclear. Six commercially bred Landrace-cross piglets were inoculated subcutaneously with 10<jats:sup>5<\/jats:sup> plaque-forming units of RVFV ZH501 strain and two piglets received a sham inoculum. All animals were monitored for clinical signs, viremia, viral shedding, and antibody response for 14 days. Piglets did not develop evidence of clinical disease, become febrile, or experience decreased weight gain during the study period. A brief lymphopenia followed by progressive lymphocytosis was observed following inoculation in all piglets. Four piglets developed a brief viremia for 2 days post-inoculation and three of these had detectable virus in oronasal secretions three days post-inoculation. Primary inoculated piglets seroconverted and those that developed detectable viremias had the highest titers assessed by serum neutralization (1:64\u20131:256). Two viremic piglets had a lymphoplasmacytic encephalitis with glial nodules; RVFV was not detected by immunohistochemistry in these sections. While young piglets do not appear to readily develop clinical disease following RVFV infection, results suggest swine could be subclinically infected with RVFV.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0188","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T12:15:40Z","timestamp":1635164140000},"page":"182-186","source":"Crossref","is-referenced-by-count":3,"title":["Experimental Infection of Domestic Piglets (Sus scrofa) with Rift Valley Fever Virus"],"prefix":"10.4269","volume":"106","author":[{"given":"Lorelei L.","family":"Clarke","sequence":"first","affiliation":[{"name":"1Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel G.","family":"Mead","sequence":"additional","affiliation":[{"name":"2Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark G.","family":"Ruder","sequence":"additional","affiliation":[{"name":"2Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah L.","family":"Carter","sequence":"additional","affiliation":[{"name":"2Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Bloodgood","sequence":"additional","affiliation":[{"name":"2Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Howerth","sequence":"additional","affiliation":[{"name":"1Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/1\/article-p182.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/106\/1\/article-p182.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T12:09:06Z","timestamp":1641384546000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/1\/article-p182.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,5]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0188","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,5]]}}}