{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:48:44Z","timestamp":1789652924676,"version":"4.0.0"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,6]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Routine assessment of the efficacy of artemisinin-based combination therapies (ACTs) is critical for the early detection of antimalarial resistance. We evaluated the efficacy of ACTs recommended for treatment of uncomplicated malaria in five sites in Democratic Republic of the Congo (DRC): artemether-lumefantrine (AL), artesunate-amodiaquine (ASAQ), and dihydroartemisinin-piperaquine (DP). Children aged 6\u201359 months with confirmed\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    malaria were treated with one of the three ACTs and monitored. The primary endpoints were uncorrected and polymerase chain reaction (PCR)-corrected 28-day (AL and ASAQ) or 42-day (DP) cumulative efficacy. Molecular markers of resistance were investigated. Across the sites, uncorrected efficacy estimates ranged from 63% to 88% for AL, 73% to 100% for ASAQ, and 56% to 91% for DP. PCR-corrected efficacy estimates ranged from 86% to 98% for AL, 91% to 100% for ASAQ, and 84% to 100% for DP. No\n                    <jats:italic>pfk13<\/jats:italic>\n                    mutations previously found to be associated with ACT resistance were observed. Statistically significant associations were found between certain\n                    <jats:italic>pfmdr1<\/jats:italic>\n                    and\n                    <jats:italic>pfcrt<\/jats:italic>\n                    genotypes and treatment outcome. There is evidence of efficacy below the 90% cutoff recommended by WHO to consider a change in first-line treatment recommendations of two ACTs in one site not far from a monitoring site in Angola that has shown similar reduced efficacy for AL. Confirmation of these findings in future therapeutic efficacy monitoring in DRC is warranted.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.21-0214","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T09:20:53Z","timestamp":1631006453000},"page":"1067-1075","source":"Crossref","is-referenced-by-count":52,"title":["Therapeutic Efficacy of Artemisinin-Based Combination Therapies in Democratic Republic of the Congo and Investigation of Molecular Markers of Antimalarial Resistance"],"prefix":"10.4269","volume":"105","author":[{"given":"Leah F.","family":"Moriarty","sequence":"first","affiliation":[{"name":"1Malaria Branch, Centers for Disease Control and Prevention, Atlanta, Georgia;"},{"name":"2President\u2019s Malaria Initiative, Atlanta, Georgia;"},{"name":"3Georgia State University School of Public Health, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Papy Mandoko","family":"Nkoli","sequence":"additional","affiliation":[{"name":"4National Institute of Biomedical Research, Kinshasa, Democratic Republic of the Congo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris Losimba","family":"Likwela","sequence":"additional","affiliation":[{"name":"5Faculty of Medicine, University of Kisangani, Kisangani, Democratic Republic of the Congo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick Mitashi","family":"Mulopo","sequence":"additional","affiliation":[{"name":"6Tropical Medicine Department, University of Kinshasa, Kinshasa, Democratic Republic of the Congo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Mukomena","family":"Sompwe","sequence":"additional","affiliation":[{"name":"7National Malaria Control Program, Ministry of Health, Kinshasa, Democratic Republic of the Congo;"},{"name":"8Faculty of Medicine University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junior Matangila","family":"Rika","sequence":"additional","affiliation":[{"name":"6Tropical Medicine Department, University of Kinshasa, Kinshasa, Democratic Republic of the Congo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hypolite Muhindo","family":"Mavoko","sequence":"additional","affiliation":[{"name":"6Tropical Medicine Department, University of Kinshasa, Kinshasa, Democratic Republic of the Congo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samaly S.","family":"Svigel","sequence":"additional","affiliation":[{"name":"1Malaria Branch, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Jones","sequence":"additional","affiliation":[{"name":"9Liverpool School of Tropical Medicine and Hygiene Pembroke Place, Liverpool, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nsengi Y.","family":"Ntamabyaliro","sequence":"additional","affiliation":[{"name":"10Unit of Clinical Pharmacology and Pharmacovigilance University of Kinshasa, Kinshasa, Democratic Republic of the Congo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert Kutekemeni","family":"Kaputu","sequence":"additional","affiliation":[{"name":"7National Malaria Control Program, Ministry of Health, Kinshasa, Democratic Republic of the Congo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Lucchi","sequence":"additional","affiliation":[{"name":"1Malaria Branch, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gireesh","family":"Subramaniam","sequence":"additional","affiliation":[{"name":"1Malaria Branch, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mame","family":"Niang","sequence":"additional","affiliation":[{"name":"1Malaria Branch, Centers for Disease Control and Prevention, Atlanta, Georgia;"},{"name":"11President\u2019s Malaria Initiative, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aboubacar","family":"Sadou","sequence":"additional","affiliation":[{"name":"1Malaria Branch, Centers for Disease Control and Prevention, Atlanta, Georgia;"},{"name":"12United States Agency for International Development, President\u2019s Malaria Initiative, Kinshasa, Democratic Republic of the Congo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieudonn\u00e9 Mumba","family":"Ngoyi","sequence":"additional","affiliation":[{"name":"4National Institute of Biomedical Research, Kinshasa, Democratic Republic of the Congo;"},{"name":"6Tropical Medicine Department, University of Kinshasa, Kinshasa, Democratic Republic of the Congo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Jacques","family":"Muyembe Tamfum","sequence":"additional","affiliation":[{"name":"4National Institute of Biomedical Research, Kinshasa, Democratic Republic of the Congo;"},{"name":"13Biomedical Department, University of Kinshasa, Kinshasa, Democratic Republic of the Congo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Schmedes","sequence":"additional","affiliation":[{"name":"1Malaria Branch, Centers for Disease Control and Prevention, Atlanta, Georgia;"},{"name":"14Association of Public Health Laboratories, Silver Spring, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz M.","family":"Plucinski","sequence":"additional","affiliation":[{"name":"1Malaria Branch, Centers for Disease Control and Prevention, Atlanta, Georgia;"},{"name":"2President\u2019s Malaria Initiative, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Chowell-Puente","sequence":"additional","affiliation":[{"name":"3Georgia State University School of Public Health, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Halsey","sequence":"additional","affiliation":[{"name":"1Malaria Branch, Centers for Disease Control and Prevention, Atlanta, Georgia;"},{"name":"2President\u2019s Malaria Initiative, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauthier Mesia","family":"Kahunu","sequence":"additional","affiliation":[{"name":"10Unit of Clinical Pharmacology and Pharmacovigilance University of Kinshasa, Kinshasa, Democratic Republic of the Congo;"},{"name":"15Department of Pharmacology and Therapeutics, University of Kinshasa, Kinshasa, Democratic Republic of the Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/4\/article-p1067.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/105\/4\/article-p1067.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T15:12:58Z","timestamp":1633533178000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/4\/article-p1067.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,6]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0214","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,6]]}}}