{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:12:12Z","timestamp":1765807932563},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,15]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Cryptosporidial diarrhea is uncommon in immunocompetent individuals, more often seen in severely immunocompromised patients. Severe refractory cases have been described in patients with HIV\/AIDS before the advent of modern antiretroviral therapy due to an inability to mount an adequate cellular immune response. We describe an 85-year-old patient post\u2013chimeric antigen receptor T-cell therapy relapsed lymphoma who developed refractory <jats:italic>Cryptosporidium<\/jats:italic> spp. diarrhea in the setting of persistent CD4+ cytopenia. Despite receiving multiple antiparasitic agents, including failure of a prolonged course of nitazoxanide, the patient experienced persistent symptoms for 9 months with repeatedly positivity stool <jats:italic>Cryptosporidium<\/jats:italic> spp. direct fluorescent antibody (DFA) test. We highlight this case of refractory <jats:italic>Cryptosporidium<\/jats:italic> spp. and the importance of recognizing the pathogen in a non\u2013HIV-infected immunosuppressed host.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0246","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T19:44:22Z","timestamp":1625773462000},"page":"651-653","source":"Crossref","is-referenced-by-count":5,"title":["Case Report: Refractory Cryptosporidiosis after CAR T-Cell Therapy for Lymphoma"],"prefix":"10.4269","volume":"105","author":[{"given":"Caitlin A.","family":"Trottier","sequence":"first","affiliation":[{"name":"1Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina F.","family":"Yen","sequence":"additional","affiliation":[{"name":"2Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Malvar","sequence":"additional","affiliation":[{"name":"3Division of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Arnason","sequence":"additional","affiliation":[{"name":"4Department of Medical Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Avigan","sequence":"additional","affiliation":[{"name":"5Division of Hematology and Hematologic Malignancies, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn D.","family":"Alonso","sequence":"additional","affiliation":[{"name":"2Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/3\/article-p651.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/105\/3\/article-p651.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T13:02:11Z","timestamp":1632402131000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/3\/article-p651.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,15]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0246","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,15]]}}}