{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:03:49Z","timestamp":1790345029436,"version":"4.1.0"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,2]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Visceral leishmaniasis (VL) is a tropical disease endemic to Brazil. The clinical manifestations of the infection range from asymptomatic to severe. In VL, changes in lipid metabolism, such as hypocholesterolemia and hypertriglyceridemia, occur that are believed to be related to its progression and severity. This study investigated the associations between serum levels of cholesterol, triglycerides, and lipoproteins (high-density lipoprotein, low-density lipoprotein, and very low-density lipoprotein) with clinical and hematological parameters that predict severity in a case series of 83 VL patients. Severely ill patients had higher mean serum triglyceride levels than non-severely ill patients. There was a significant positive correlation between disease severity score and serum triglyceride levels, very low-density lipoprotein, international normalized ratio for prothrombin time test, total bilirubin, and age. An inverse correlation was detected between the disease severity score and mean platelet and neutrophil counts. Hypertriglyceridemia can be a prognostic indicator of severity in patients diagnosed with VL.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0260","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T23:11:46Z","timestamp":1637622706000},"page":"643-647","source":"Crossref","is-referenced-by-count":9,"title":["Association between Hypertriglyceridemia and Disease Severity in Visceral Leishmaniasis"],"prefix":"10.4269","volume":"106","author":[{"given":"Mariana Garcez","family":"Varela","sequence":"first","affiliation":[{"name":"1Immunology and Molecular Biology Laboratory, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil;"},{"name":"2Endocrinology Service from the University Hospital\/EBSERH, Federal University of Sergipe, Aracaju, Sergipe, Brazil;"},{"name":"3Heath Science Graduate Program, Aracaju, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"de Oliveira Bezerra","sequence":"additional","affiliation":[{"name":"1Immunology and Molecular Biology Laboratory, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Vieira","family":"Santana","sequence":"additional","affiliation":[{"name":"1Immunology and Molecular Biology Laboratory, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Couto","family":"Gomes","sequence":"additional","affiliation":[{"name":"1Immunology and Molecular Biology Laboratory, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Ribeiro","family":"de Jesus Almeida","sequence":"additional","affiliation":[{"name":"4Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Belo Horizonte, Minas Gerais, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geydson","family":"Silveira da Cruz","sequence":"additional","affiliation":[{"name":"3Heath Science Graduate Program, Aracaju, Brazil;"},{"name":"5Hematology Service, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enaldo Vieira","family":"de Melo","sequence":"additional","affiliation":[{"name":"6Pediatric Clinic, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Roberto","family":"de Oliveira Costa","sequence":"additional","affiliation":[{"name":"7Infectious Disease Clinic, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabr\u00edcia Alvisi","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"1Immunology and Molecular Biology Laboratory, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lia Ribeiro","family":"de Jesus","sequence":"additional","affiliation":[{"name":"1Immunology and Molecular Biology Laboratory, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil;"},{"name":"3Heath Science Graduate Program, Aracaju, Brazil;"},{"name":"8Immunology Investigative Institute, INCT, CNPq, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roque Pacheco","family":"de Almeida","sequence":"additional","affiliation":[{"name":"1Immunology and Molecular Biology Laboratory, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil;"},{"name":"3Heath Science Graduate Program, Aracaju, Brazil;"},{"name":"8Immunology Investigative Institute, INCT, CNPq, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/2\/article-p643.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/106\/2\/article-p643.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T14:58:01Z","timestamp":1643813881000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/2\/article-p643.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,2]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0260","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,2]]}}}