{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:08:24Z","timestamp":1789459704408,"version":"build-2803163510"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,15]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Cystic echinococcosis (CE) is a parasitic disease caused by the larval forms of species of the tapeworm <jats:italic>Echinococcus<\/jats:italic>. The most common location is the liver. To assess the frequency and clinical characteristics of portal hypertension (PH) and the risk factors for PH development, we performed a retrospective observational study of inpatients diagnosed with hepatic CE and PH from January 1998 to December 2018, at Complejo Asistencial Universitario de Salamanca, Spain. Of 362 patients analyzed with hepatic CE, 15 inpatients (4.1%) had a portal vein diameter \u2265\u200914 mm, and the mean diameter of the portal vein was 16.9 (standard deviation [SD] \u00b12.1) mm. Twelve patients were men. The mean age was 59.5 years (SD \u00b1 17.8 years). Four patients had ascites (26.6%), four had collateral circulation (26.6%), 14 had hepatosplenomegaly (93.3%), five had esophageal varices (33.3%), four had hematemesis, and three had jaundice. Other causes of PH included hepatitis B virus (1 patient) and hepatitis C virus (1 patient) infections and alcohol abuse (1 patient). The host variables associated with PH development were male sex (odds ratio, 4.6; 95% confidence interval, 1.1\u201320.9; <jats:italic>P<\/jats:italic> = 0.030) and larger cyst size (10.8 \u00b1 6.3 versus 7.6 \u00b1 4.1; <jats:italic>P<\/jats:italic> = 0.004). Hepatic CE is an infrequent cause of PH that usually occurs without indications of liver failure. Larger cyst size and male sex were the main risk factors associated with this complication. Mortality was higher for patients with hepatic CE with PH than for patients with hepatic CE without PH.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0274","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T11:45:13Z","timestamp":1626695113000},"page":"692-697","source":"Crossref","is-referenced-by-count":5,"title":["Portal Hypertension as a Complication of Cystic Echinococcosis: A 20-Year Cohort Analysis"],"prefix":"10.4269","volume":"105","author":[{"given":"Javier","family":"Collado Aliaga","sequence":"first","affiliation":[{"name":"1Servicio de Medicina Interna, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela","family":"Romero-Alegr\u00eda","sequence":"additional","affiliation":[{"name":"2Servicio de Medicina Interna, Complejo Asistencial Universitario de Salamanca, Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca, Centro de Investigaci\u00f3n de Enfermedades Tropicales de la Universidad de Salamanca, Universidad de Salamanca, Salamanca, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Alonso-Sard\u00f3n","sequence":"additional","affiliation":[{"name":"3\u00c1rea de Medicina Preventiva y Salud P\u00fablica, Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca, Centro de Investigaci\u00f3n de Enfermedades Tropicales de la Universidad de Salamanca, Universidad de Salamanca, Salamanca, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Prieto-Vicente","sequence":"additional","affiliation":[{"name":"4Servicio de Digestivo, Complejo Asistencial Universitario de Salamanca, Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca, Salamanca, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amparo","family":"L\u00f3pez-Bernus","sequence":"additional","affiliation":[{"name":"5Servicio de Medicina Interna, Secci\u00f3n de Enfermedades Infecciosas, Complejo Asistencial Universitario de Salamanca, Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca, Centro de Investigaci\u00f3n de Enfermedades Tropicales de la Universidad de Salamanca, Salamanca, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Velasco-Tirado","sequence":"additional","affiliation":[{"name":"6Servicio de Dermatolog\u00eda, Complejo Asistencial Universitario de Salamanca, Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca, Centro de Investigaci\u00f3n de Enfermedades Tropicales de la Universidad de Salamanca, Salamanca, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Sendra de la Ossa","sequence":"additional","affiliation":[{"name":"7Secci\u00f3n de Enfermedades Infecciosas, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Pardo-Lledias","sequence":"additional","affiliation":[{"name":"8Servicio de Medicina Interna, Hospital Marqu\u00e9s de Valdecilla Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla, Avenida Valdecilla SN, 39008 Santander, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moncef","family":"Belhassen-Garc\u00eda","sequence":"additional","affiliation":[{"name":"9Servicio de Medicina Interna, Secci\u00f3n de Enfermedades Infecciosas, Complejo Asistencial Universitario de Salamanca, Instituto de investigaci\u00f3n Biom\u00e9dica de Salamanca, Centro de Investigaci\u00f3n de Enfermedades Tropicales de la Universidad de Salamanca, Universidad de Salamanca, Paseo San Vicente 58-182, 37007, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/3\/article-p692.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/105\/3\/article-p692.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T13:03:33Z","timestamp":1632402213000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/3\/article-p692.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,15]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0274","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,15]]}}}