{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:01:45Z","timestamp":1773792105942,"version":"3.50.1"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,6]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>We determined the prevalence of Kelch 13 mutations and <jats:italic>pfmdr1<\/jats:italic> copy number in samples collected from the Thailand\u2013Myanmar border, the Thailand\u2013Cambodia border, and southern Thailand from 2002 to 2007. C580Y was the most prevalent in Trat (Thailand\u2013Cambodia border) and Ranong (Thailand\u2013Myanmar border) at 42% (24\/57) and 13% (6\/48), respectively. Less predominant mutations were also identified including R539T (7%, 4\/57) and Y493H (2%, 1\/57) in Trat, P574L (6%, 3\/48) and P553L (2%, 1\/48) in Ranong, and N537I and D452E (7%, 1\/15) in Sangkhlaburi (Thailand\u2013Myanmar border). Samples from Mae sot (33%, 11\/33) harbored the highest percentage of multiple <jats:italic>pfmdr1<\/jats:italic> copies, followed by Trat (18%, 10\/57), Chiang Dao in 2003 (13%, 4\/30), Phang Nga (5%, 2\/44), and Chiang Dao in 2002 (4%, 1\/26). This retrospective study provides geographic diversity of K13 and <jats:italic>pfmdr1<\/jats:italic> copies and the emergence of these molecular markers in Thailand, an important background information for future surveillance in the region.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0303","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T12:26:17Z","timestamp":1626438377000},"page":"1093-1096","source":"Crossref","is-referenced-by-count":7,"title":["Molecular Detection of Mutations in the Propeller Domain of Kelch 13 and pfmdr1 Copy Number Variation in Plasmodium falciparum Isolates from Thailand Collected from 2002 to 2007"],"prefix":"10.4269","volume":"105","author":[{"given":"Chaiyaporn","family":"Chaisatit","sequence":"first","affiliation":[{"name":"1Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piyaporn","family":"Sai-ngam","sequence":"additional","affiliation":[{"name":"1Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasikanya","family":"Thaloengsok","sequence":"additional","affiliation":[{"name":"1Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabaithip","family":"Sriwichai","sequence":"additional","affiliation":[{"name":"1Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisada","family":"Jongsakul","sequence":"additional","affiliation":[{"name":"1Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Fukuda","sequence":"additional","affiliation":[{"name":"2Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Spring","sequence":"additional","affiliation":[{"name":"1Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariusz","family":"Wojnarski","sequence":"additional","affiliation":[{"name":"1Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman","family":"Waters","sequence":"additional","affiliation":[{"name":"1Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paphavee","family":"Lertsethtakarn","sequence":"additional","affiliation":[{"name":"1Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian A.","family":"Vesely","sequence":"additional","affiliation":[{"name":"1Department of Bacterial and Parasitic Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/4\/article-p1093.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/105\/4\/article-p1093.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T19:13:01Z","timestamp":1633547581000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/4\/article-p1093.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,6]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0303","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,6]]}}}