{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:11:04Z","timestamp":1788297064662,"version":"build-2803163510"},"reference-count":59,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,14]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>The relationship of retinol binding protein 4 (RBP4) with biomarkers of intestinal health and gut integrity in adults is unknown. We sought to determine the correlation between plasma RBP4 level and BMI and investigate the relationship of circulating RBP4 concentration with biomarkers of environmental enteric dysfunction among lean adults (body mass index [BMI] &lt;\u00a025.0 kg\/m<jats:sup>2<\/jats:sup>) in Bangladesh. Overall, 270 adults (135 undernourished with a BMI &lt;\u00a018.5 kg\/m<jats:sup>2<\/jats:sup> and 135 healthy controls with a BMI between 18.5 and 24.9 kg\/m<jats:sup>2<\/jats:sup>) aged 18 to 45 years were evaluated. Multivariable linear regression was performed to test the association between RBP4 and fecal biomarkers of impaired gut health. RBP4 concentration was positively correlated (rho = 0.27, <jats:italic>P<\/jats:italic> &lt; 0.001) with BMI and was significantly higher in healthy controls than undernourished adults (<jats:italic>P<\/jats:italic> &lt; 0.001), in male than female (<jats:italic>P<\/jats:italic> &lt; 0.001), and also in employed (<jats:italic>P<\/jats:italic> &lt; 0.001), smokers (<jats:italic>P<\/jats:italic> = 0.048) and participants with low Self-Reporting Questionnaire (SRQ)\u201420 scores (an instrument to screen mental health disorders) (<jats:italic>P<\/jats:italic> = 0.049). Statistically significant negative correlations were observed between RBP4 and fecal biomarkers of gut enteropathy including myeloperoxidase (rho = \u20130.23, <jats:italic>P<\/jats:italic> &lt; 0.001), neopterin (rho = \u20130.30, <jats:italic>P<\/jats:italic> &lt; 0.001), and alpha-1 anti-trypsin (rho = \u20130.21, <jats:italic>P<\/jats:italic> &lt; 0.001). Multivariable linear regression analysis showed that increased RBP4 concentration was associated with a significant reduction in fecal neopterin (coefficient = \u20130.95; 95% confidence interval: \u20131.44 to \u20130.45]; <jats:italic>P<\/jats:italic> &lt; 0.001) after adjustment for age, sex, nutritional status at enrollment, education, dietary diversity score, SRQ-20 score, improved sanitation, household animal exposure, and alpha-1-acid glycoprotein. The study findings revealed an inverse relationship of plasma RBP4 concentration with fecal biomarkers of altered gut health among slum-dwelling lean adults in Bangladesh.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0322","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T12:53:29Z","timestamp":1665406409000},"page":"1315-1322","source":"Crossref","is-referenced-by-count":2,"title":["Association between Circulating Retinol Binding Protein 4, Body Mass Index, and Biomarkers of Environmental Enteric Dysfunction among Slum-Dwelling Lean Adults in Bangladesh"],"prefix":"10.4269","volume":"107","author":[{"given":"Shah Mohammad","family":"Fahim","sequence":"first","affiliation":[{"name":"Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Amran","family":"Gazi","sequence":"additional","affiliation":[{"name":"Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Ashraful","family":"Alam","sequence":"additional","affiliation":[{"name":"Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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