{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T23:26:43Z","timestamp":1668382003695},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>The RTS,S\/AS01 malaria vaccine confers only moderate protection against malaria. Evidence suggests that the effectiveness of the RTS,S\/AS01 vaccine depends upon the parasite population genetics, specifically regarding the circumsporozoite protein haplotypes in the population. We investigated <jats:italic>Plasmodium falciparum<\/jats:italic> circumsporozoite protein (PfCSP) gene sequences from two endemic sites in 2018 in Senegal. The PfCSP sequences were compared with those retrieved from the Pf3k genome database. In the central repeat region of PfCSP, the distribution of haplotypes differed significantly between the two study sites (Fisher\u2019s exact test, <jats:italic>P<\/jats:italic> &lt; 0.001). No 3D7 vaccine strain haplotype was observed in this locus. In the C-terminal region, there was no significant difference in haplotypes distribution between Kedougou and Diourbel (Fischer\u2019s exact test, <jats:italic>P<\/jats:italic> = 0.122). The 3D7 haplotype frequency was 8.4% in early samples (2001\u20132011), but then it contracted in the subsequent years. The extensive plasticity of the <jats:italic>P. falciparum<\/jats:italic> genes coding the RTS,S\/AS01 vaccine target antigens may influence the immune responses to circulating alleles. Monitoring the genetic diversity baseline and its dynamics over time and space would be instrumental in rationally improving the malaria RTS,S\/AS01 vaccine and\/or its implementation schedule.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0369","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T13:55:35Z","timestamp":1633960535000},"page":"1738-1746","source":"Crossref","is-referenced-by-count":1,"title":["Spatiotemporal Dynamic of the RTS,S\/AS01 Malaria Vaccine Target Antigens in Senegal"],"prefix":"10.4269","volume":"105","author":[{"given":"Mamadou Alpha","family":"Diallo","sequence":"first","affiliation":[{"name":"1Department of Parasitology and Mycology, Cheikh Anta Diop University, Dakar, Senegal;"},{"name":"2Aristide Le Dantec University Hospital, Dakar, Senegal;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coralie","family":"L\u2019Ollivier","sequence":"additional","affiliation":[{"name":"3Aix Marseille University, IRD, AP-HM, SSA, VITROME, Marseille, France;"},{"name":"4IHU M\u00e9diterran\u00e9e Infection, Marseille, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadim","family":"Diongue","sequence":"additional","affiliation":[{"name":"1Department of Parasitology and Mycology, Cheikh Anta Diop University, Dakar, Senegal;"},{"name":"2Aristide Le Dantec University Hospital, Dakar, Senegal;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida Sadikh","family":"Badiane","sequence":"additional","affiliation":[{"name":"1Department of Parasitology and Mycology, Cheikh Anta Diop University, Dakar, Senegal;"},{"name":"2Aristide Le Dantec University Hospital, Dakar, Senegal;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aly","family":"Kodio","sequence":"additional","affiliation":[{"name":"3Aix Marseille University, IRD, AP-HM, SSA, VITROME, Marseille, France;"},{"name":"4IHU M\u00e9diterran\u00e9e Infection, Marseille, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamadou Lamine","family":"Tall","sequence":"additional","affiliation":[{"name":"3Aix Marseille University, IRD, AP-HM, SSA, VITROME, Marseille, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mouhamad","family":"Sy","sequence":"additional","affiliation":[{"name":"1Department of Parasitology and Mycology, Cheikh Anta Diop University, Dakar, Senegal;"},{"name":"2Aristide Le Dantec University Hospital, Dakar, Senegal;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mame Cheikh","family":"Seck","sequence":"additional","affiliation":[{"name":"1Department of Parasitology and Mycology, Cheikh Anta Diop University, Dakar, Senegal;"},{"name":"2Aristide Le Dantec University Hospital, Dakar, Senegal;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doudou","family":"Sene","sequence":"additional","affiliation":[{"name":"4IHU M\u00e9diterran\u00e9e Infection, Marseille, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mouhamadou","family":"Ndiaye","sequence":"additional","affiliation":[{"name":"1Department of Parasitology and Mycology, Cheikh Anta Diop University, Dakar, Senegal;"},{"name":"2Aristide Le Dantec University Hospital, Dakar, Senegal;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatou Ba","family":"Fall","sequence":"additional","affiliation":[{"name":"5National Malaria Control Program (NMCP), Dakar, Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Ranque","sequence":"additional","affiliation":[{"name":"3Aix Marseille University, IRD, AP-HM, SSA, VITROME, Marseille, France;"},{"name":"4IHU M\u00e9diterran\u00e9e Infection, Marseille, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daouda","family":"Ndiaye","sequence":"additional","affiliation":[{"name":"1Department of Parasitology and Mycology, Cheikh Anta Diop University, Dakar, Senegal;"},{"name":"2Aristide Le Dantec University Hospital, Dakar, Senegal;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/6\/article-p1738.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/105\/6\/article-p1738.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T23:02:17Z","timestamp":1638399737000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/6\/article-p1738.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0369","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,1]]}}}