{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:12:52Z","timestamp":1788793972276,"version":"build-2803163510"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Schistosomiasis is the second most important parasitic infection after malaria in terms of its socioeconomic impact and is endemic in 78 countries. It affects more than 240 million people worldwide, with 90% of cases occurring in sub-Saharan Africa. In Uganda,\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    is the most common species, with more than seven million people infected and 17 million living at risk despite mass drug administration (MDA) of praziquantel initiated more than 16 years ago. There has been a shift in the WHO schistosomiasis goals from controlling morbidity to elimination as a public health problem. Understanding the drivers of infection in persistent transmission hotspots despite ongoing control interventions is paramount. We conducted a cross-sectional epidemiological study of 381 individuals in Bugoto community, Mayuge district, Eastern Uganda, along with a structured survey to ascertain drivers of\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    infection. Bugoto has had community-wide MDA since 2004. We detected a\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    prevalence of 52% across the whole community and a prevalence of 71% in school-age children. This qualifies Bugoto as a highly endemic community according to WHO guidelines. Using a multivariate logistic regression, we found that\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    infection was best explained by age group, longer residence times, and any daily contact with lake water.\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    infection remains a large burden across this community. This study identifies opportunities for interventions that reduce lake water contact, expand treatment eligibility to all at risk, and improve MDA coverage for long-term residents in these settings to control schistosomiasis in persistent transmission hotspots.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.21-0391","type":"journal-article","created":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T14:46:13Z","timestamp":1634568373000},"page":"1772-1781","source":"Crossref","is-referenced-by-count":25,"title":["Residence Time, Water Contact, and Age-driven Schistosoma mansoni Infection in Hotspot Communities in Uganda"],"prefix":"10.4269","volume":"105","author":[{"given":"Arinaitwe","family":"Moses","sequence":"first","affiliation":[{"name":"1Vector Borne and Neglected Tropical Diseases Control Division, Ministry of Health, Kampala, Uganda;"},{"name":"2Cavendish University Uganda, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Adriko","sequence":"additional","affiliation":[{"name":"1Vector Borne and Neglected Tropical Diseases Control Division, Ministry of Health, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Kibwika","sequence":"additional","affiliation":[{"name":"2Cavendish University Uganda, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edridah M.","family":"Tukahebwa","sequence":"additional","affiliation":[{"name":"1Vector Borne and Neglected Tropical Diseases Control Division, Ministry of Health, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina L.","family":"Faust","sequence":"additional","affiliation":[{"name":"3Institute for Biodiversity, Animal Health and Comparative Medicine and Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poppy H. L.","family":"Lamberton","sequence":"additional","affiliation":[{"name":"3Institute for Biodiversity, Animal Health and Comparative Medicine and Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/6\/article-p1772.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/105\/6\/article-p1772.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T18:02:30Z","timestamp":1638381750000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/6\/article-p1772.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0391","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,1]]}}}