{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:20:27Z","timestamp":1761218427724},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,5]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Magnetic resonance images from 197 patients with calcified neurocysticercosis (NCC), 38 with viable NCC and 197 NCC-free healthy rural villagers were evaluated to compare the frequency of hippocampal atrophy\/sclerosis (HAS) across these populations. Scheltens\u2019 medial temporal atrophy scale was used for hippocampal rating. The median age of the 432 study participants was 46 years (interquartile range, 29\u201362 years), and 58% were women. Hippocampal atrophy\/sclerosis was disclosed in 26.9% patients with calcified NCC, compared with 7.9% in patients with viable NCC and 8.1% in healthy rural villagers. After adjusting for age, gender, and history of epilepsy, hippocampal atrophy\/sclerosis was more frequent in patients with calcified NCC than in those with viable cysts (RR, 3.60; 95% CI, 1.18\u2013 0.99; <jats:italic>P<\/jats:italic>\u2009=\u20090.025) and healthy rural villagers (RR, 3.43; 95% CI, 1.94\u20136.06; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), suggesting that hippocampal damage develops late in the course of this parasitic disease.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0392","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T12:15:51Z","timestamp":1635164151000},"page":"215-218","source":"Crossref","is-referenced-by-count":8,"title":["Hippocampal Atrophy\/Sclerosis Is Associated with Old, Calcified Parenchymal Brain Neurocysticercosis, But Not with More Recent, Viable Infections"],"prefix":"10.4269","volume":"106","author":[{"given":"Sof\u00eda S.","family":"S\u00e1nchez","sequence":"first","affiliation":[{"name":"1Center for Global Health, Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier A.","family":"Bustos","sequence":"additional","affiliation":[{"name":"1Center for Global Health, Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru;"},{"name":"2Cysticercosis Unit, Instituto Nacional de Ciencias Neurol\u00f3gicas, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar H.","family":"Del Brutto","sequence":"additional","affiliation":[{"name":"3School of Medicine, Universidad Esp\u00edritu Santo\u2013Ecuador, Samborond\u00f3n, Ecuador;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genaro","family":"Herrera","sequence":"additional","affiliation":[{"name":"2Cysticercosis Unit, Instituto Nacional de Ciencias Neurol\u00f3gicas, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Carlos","family":"dos Santos","sequence":"additional","affiliation":[{"name":"4Centro de Cirurgia de Epilepsia, Faculdade de Medicina, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Javier Pretell","sequence":"additional","affiliation":[{"name":"2Cysticercosis Unit, Instituto Nacional de Ciencias Neurol\u00f3gicas, Lima, Peru;"},{"name":"5Department of Neurology, Hospital Alberto Sabogal, Callao, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isidro","family":"Gonzales","sequence":"additional","affiliation":[{"name":"2Cysticercosis Unit, Instituto Nacional de Ciencias Neurol\u00f3gicas, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Saavedra","sequence":"additional","affiliation":[{"name":"2Cysticercosis Unit, Instituto Nacional de Ciencias Neurol\u00f3gicas, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor H.","family":"Garcia","sequence":"additional","affiliation":[{"name":"1Center for Global Health, Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru;"},{"name":"2Cysticercosis Unit, Instituto Nacional de Ciencias Neurol\u00f3gicas, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"_","family":"_","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/1\/article-p215.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/106\/1\/article-p215.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T12:08:51Z","timestamp":1641384531000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/1\/article-p215.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,5]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0392","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,5]]}}}