{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:29:32Z","timestamp":1772173772793,"version":"3.50.1"},"reference-count":54,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>We identified the determinants of positive (children who had a birth weight &lt;\u00a02.5 kg and\/or maternal height &lt;\u00a0145 cm but were nonstunted at 24 months of age) and negative (children who had a birth weight \u2265\u00a02.5 kg and maternal height \u2265\u00a0145 cm but were stunted at 24 months of age) deviance in childhood linear growth. We found that socioeconomic status (\u03b2 = 1.54, <jats:italic>P<\/jats:italic> &lt; 0.01), serum retinol (\u03b2 = 0.05, <jats:italic>P<\/jats:italic> &lt; 0.01), hemoglobin (\u03b2 = 0.36, <jats:italic>P<\/jats:italic> &lt; 0.01), length-for-age Z-score (LAZ) at birth (\u03b2 = 0.47, <jats:italic>P<\/jats:italic> &lt; 0.01), and tetanus vaccine titer (\u03b2 = 0.182, <jats:italic>P<\/jats:italic> &lt; 0.05) were positively and maternal depressive symptom (\u03b2 = \u20130.05, <jats:italic>P<\/jats:italic> &lt; 0.01), serum ferritin (\u03b2 = \u20130.03, <jats:italic>P<\/jats:italic> &lt; 0.01), male sex (\u03b2 = \u20131.08, <jats:italic>P<\/jats:italic> &lt; 0.01), and \u03b11-antitrypsin (\u03b2 = \u20130.81, <jats:italic>P<\/jats:italic> &lt; 0.01) were negatively associated with positive deviance. Further, diarrhea episodes (\u03b2 = 0.02, <jats:italic>P<\/jats:italic> &lt; 0.01), male sex (\u03b2 = 0.72, <jats:italic>P<\/jats:italic> &lt; 0.01), and \u03b11-antitrypsin (\u03b2 = 0.67, <jats:italic>P<\/jats:italic> &lt; 0.01) were positively and hemoglobin (\u03b2= \u20130.28, <jats:italic>P<\/jats:italic> &lt; 0.01), soluble transferrin receptor level (\u03b2 = \u20130.15, <jats:italic>P<\/jats:italic> &lt; 0.01), and LAZ score at birth (\u03b2 = \u20130.90, <jats:italic>P<\/jats:italic> &lt; 0.01) were negatively associated with negative deviance. To summarize, enteric protein loss, micronutrient deficiency, vaccine responses and maternal depressive symptoms were associated with linear growth deviance in early childhood. In such a background, public health approaches aimed at reducing the risk of intestinal inflammation and altered gut permeability could prove fruitful in ensuring desired linear growth in children. In addition, maternal mental health issue should also be considered, especially for promoting better nutritional status in children in the context of linear growth deviance.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0403","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T12:56:27Z","timestamp":1649681787000},"page":"1732-1740","source":"Crossref","is-referenced-by-count":3,"title":["Associations of Enteric Protein Loss, Vaccine Response, Micronutrient Deficiency, and Maternal Depressive Symptoms with Deviance in Childhood Linear Growth: Results from a Multicountry Birth Cohort Study"],"prefix":"10.4269","volume":"106","author":[{"given":"Subhasish","family":"Das","sequence":"first","affiliation":[{"name":"Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh;"},{"name":"Liggins Institute, University of Auckland, Auckland, New Zealand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Visnu Pritom","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Amran","family":"Gazi","sequence":"additional","affiliation":[{"name":"Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shah Mohammad","family":"Fahim","sequence":"additional","affiliation":[{"name":"Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Ashraful","family":"Alam","sequence":"additional","affiliation":[{"name":"Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Mahfuz","sequence":"additional","affiliation":[{"name":"Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esto","family":"Mduma","sequence":"additional","affiliation":[{"name":"Haydom Global Health Institute, Haydom, Tanzania;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahmeed","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh;"},{"name":"James P. 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