{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T05:13:30Z","timestamp":1718601210596},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,5]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>We present a case of primary infertility with features of hypogonadism in a male patient with lepromatous leprosy who had remained undiagnosed for 3 years. On investigation, azoospermia and deranged gonadotropin levels with normal serum testosterone were noted and the patient was initiated on multibacillary\u2013multidrug therapy with the primary aim of treating the disease. Although the cutaneous lesions improved within 6 weeks, remarkably infertility was reversed in 2 months\u2014with concomitant normalization of luteinizing hormone, follicle stimulating hormone, and sperm count\u2014an outcome that was unexpected. While reiterating leprosy as a cause of infertility, we discuss the probable mechanism for the efficacy of multidrug therapy in what seemed to be an irreversible outcome of advanced lepromatous leprosy.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0536","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T12:15:09Z","timestamp":1635164109000},"page":"47-50","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Successful Outcome of Primary Infertility with Multidrug Therapy in a Long-Standing Case of Hypogonadism Resulting from Lepromatous Leprosy: Shattering the Dogma of Irreversible Infertility in Leprosy"],"prefix":"10.4269","volume":"106","author":[{"given":"Surabhi","family":"Sinha","sequence":"first","affiliation":[{"name":"1Department of Dermatology, Venereology and Leprosy, ABVIMS & Dr. Ram Manohar Lohia Hospital, New Delhi, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sweta","family":"Singh","sequence":"additional","affiliation":[{"name":"1Department of Dermatology, Venereology and Leprosy, ABVIMS & Dr. Ram Manohar Lohia Hospital, New Delhi, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinu Rose","family":"Mathachan","sequence":"additional","affiliation":[{"name":"1Department of Dermatology, Venereology and Leprosy, ABVIMS & Dr. Ram Manohar Lohia Hospital, New Delhi, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bathula","family":"Savitha","sequence":"additional","affiliation":[{"name":"1Department of Dermatology, Venereology and Leprosy, ABVIMS & Dr. Ram Manohar Lohia Hospital, New Delhi, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kabir","family":"Sardana","sequence":"additional","affiliation":[{"name":"1Department of Dermatology, Venereology and Leprosy, ABVIMS & Dr. Ram Manohar Lohia Hospital, New Delhi, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Purnima","family":"Malhotra","sequence":"additional","affiliation":[{"name":"2Department of Pathology, ABVIMS and Dr. Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/1\/article-p47.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/106\/1\/article-p47.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T12:09:02Z","timestamp":1641384542000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/1\/article-p47.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,5]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0536","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,5]]}}}