{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T01:14:42Z","timestamp":1782177282739,"version":"3.54.5"},"reference-count":31,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","license":[{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,5]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Neglected tropical diseases (NTDs) receive relatively little research and development but have a tremendous impact on lifespan and livelihood. Here, we use existing data on the need for drugs, their efficacy, and their treatment percentages to estimate the impacts of various regimens on the global burden of several NTDs: schistosomiasis, onchocerciasis, lymphatic filariasis, and three soil-transmitted helminths (STHs) over time. For an interactive visualization of our models\u2019 results, see <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.global-health-impact.org\/\" xlink:type=\"simple\">https:\/\/www.global-health-impact.org\/<\/jats:ext-link>. In 2015, our NTD models estimate that treatment averted 2,778,131.78 disability-adjusted life years (DALYs). Together, treatments targeting STHs together averted 51.05% of the DALYs averted from all NTD treatments, whereas schistosomiasis, lymphatic filariasis, and onchocerciasis medicines averted 40.21%, 7.56%, and 1.18%, respectively. Our models highlight the importance of focusing not just on the burden of these diseases but also on their alleviation in the effort to expand access to treatment.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0583","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T13:37:04Z","timestamp":1677505024000},"page":"801-806","source":"Crossref","is-referenced-by-count":7,"title":["Global Health Impact: A Model to Alleviate the Burden and Expand Access to Treatment of Neglected Tropical Diseases"],"prefix":"10.4269","volume":"108","author":[{"given":"Nicole","family":"Hassoun","sequence":"first","affiliation":[{"name":"Department of Philosophy, Binghamton University, Binghamton, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Cosler","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Binghamton University, Binghamton, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","year":"2018"},{"key":"b2","year":"2017"},{"key":"b3","series-title":"J Health Care Poor Underserved","first-page":"53","article-title":"Neglected tropical diseases: infection, modeling, and control","volume":"21","author":"Kealey","year":"2010"},{"key":"b4","series-title":"Clin Infect Dis","first-page":"923","article-title":"Reaching the London Declaration on Neglected Tropical Diseases goals for onchocerciasis: an economic evaluation of increasing the frequency of ivermectin treatment in Africa","volume":"59","author":"Turner","year":"2014"},{"key":"b5","series-title":"Am J Trop Med Hyg","first-page":"773","article-title":"Modeling the effect of chronic schistosomiasis on childhood development and the potential for catch-up growth with different drug treatment strategies promoted for control of endemic schistosomiasis","volume":"84","author":"Gurarie","year":"2011"},{"key":"b6","series-title":"BMC Public Health","first-page":"265","article-title":"Mathematical analysis of a lymphatic filariasis model with quarantine and treatment","volume":"17","author":"Mwamtobe","year":"2017"},{"key":"b7","series-title":"BMC Infect Dis","first-page":"20","article-title":"Patterns of soil-transmitted helminth infection and impact of four-monthly albendazole treatments in preschool children from semi-urban communities in Nigeria: a double-blind placebo-controlled randomised trial","volume":"9","author":"Kirwan","year":"2009"},{"key":"b8","series-title":"PLoS Negl Trop Dis","first-page":"293","article-title":"Impact of long-term treatment with ivermectin on the prevalence and intensity of soil-transmitted helminth infections","volume":"2","author":"Moncayo","year":"2008"},{"key":"b9","series-title":"Parasitology","first-page":"1583","article-title":"LYMFASIM, a simulation model for predicting the impact of lymphatic filariasis control: quantification for African villages","volume":"135","author":"Stolk","year":"2008"},{"key":"b10","series-title":"Filaria J","first-page":"5","article-title":"Advances and challenges in predicting the impact of lymphatic filariasis elimination programmes by mathematical modelling","volume":"5","author":"Stolk","year":"2006"},{"key":"b11","series-title":"Parasit Vectors","first-page":"501","article-title":"Mathematical modelling of lymphatic filariasis elimination programmes in India: required duration of mass drug administration and post-treatment level of infection indicators","volume":"9","author":"Jambulingam","year":"2016"},{"key":"b12","year":"2010"},{"key":"b13","series-title":"Parasitol Today","first-page":"438","article-title":"The global burden of intestinal nematode infections\u2014fifty years on","volume":"13","author":"Chan","year":"1997"},{"key":"b14","series-title":"Vaccine","first-page":"1201","article-title":"The potential economic value of a hookworm vaccine","volume":"29","author":"Lee","year":"2011"},{"key":"b15","series-title":"Parasit Vectors","first-page":"355","article-title":"Cost and cost-effectiveness of soil-transmitted helminth treatment programmes: systematic review and research needs","volume":"8","author":"Turner","year":"2015"},{"key":"b16","series-title":"Trop Med Int Health","first-page":"737","article-title":"Impact of seven rounds of mass administration of diethylcarbamazine and ivermectin on prevalence of chronic lymphatic filariasis in south India","volume":"13","author":"Yuvaraj","year":"2008"},{"key":"b17","series-title":"Bull World Health Organ","first-page":"384","article-title":"Can ivermectin mass treatments eliminate onchocerciasis in Africa?","volume":"80","author":"Winnen","year":"2002"},{"key":"b18","series-title":"BMC Med","first-page":"27","article-title":"Parasitological impact of 2-year preventive chemotherapy on schistosomiasis and soil-transmitted helminthiasis in Uganda","volume":"5","author":"Zhang","year":"2007"},{"key":"b19","series-title":"J R Soc Interface","first-page":"1329","article-title":"Modelling heterogeneity and the impact of chemotherapy and vaccination against human hookworm","volume":"5","author":"Sabatelli","year":"2008"},{"key":"b20","series-title":"PLoS Negl Trop Dis","first-page":"3319","article-title":"Progress and impact of 13 years of the global programme to eliminate lymphatic filariasis on reducing the burden of filarial disease","volume":"8","author":"Ramaiah","year":"2014"},{"key":"b21","series-title":"Int Health","first-page":"3","article-title":"For as long as necessary: examining 30 years of MSD\u2019s focus on achieving elimination of onchocerciasis and lymphatic filariasis","volume":"10","author":"Gustavsen","year":"2018"},{"key":"b22","series-title":"PLoS Negl Trop Dis","first-page":"1","article-title":"The NTD Supply Chain Forum\u2014strengthening the backbone of NTD programs","volume":"14","author":"Souza","year":"2020"},{"key":"b23","author":"Hassoun","year":"2022"},{"key":"b24","author":"Hassoun","year":"2020"},{"key":"b25","year":"2015"},{"key":"b26","author":"Crompton","year":"2006"},{"key":"b27"},{"key":"b28","year":"2021"},{"key":"b29","series-title":"Trop Med Infect Dis","first-page":"36","article-title":"Neglected tropical diseases: epidemiology and global burden","volume":"2","author":"Mitra","year":"2017"},{"key":"b30","series-title":"Clin Ther","first-page":"1193","article-title":"Progress report on neglected tropical disease drug donation programs","volume":"38","author":"Cohen","year":"2016"},{"key":"b31","year":"2016"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/108\/4\/article-p801.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/108\/4\/article-p801.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/108\/4\/article-p801.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T15:12:46Z","timestamp":1680707566000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/108\/4\/article-p801.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,5]]},"references-count":31,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0583","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,5]]}}}