{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:47:32Z","timestamp":1788929252196,"version":"build-2803163510"},"reference-count":15,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,13]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>We report an outbreak of typhoid fever between April and June 2019 in the Surveillance for Enteric Fever in India cohort, a pediatric cohort from four contiguous semi-urban settlements of Vellore in South India. This cohort of children 6 months to 15 years of age was under surveillance from October 2017 to December 2019. A clustering of typhoid cases in the cohort was noted with reference to time, place, and person. The overall typhoid attack rate in the cohort was 0.9%, with the highest attack rate of 1.7% being documented in one of the four areas. The rate of hospitalization and complications in children who were typhoid positive during the outbreak was 28% and 2%, respectively. Given the background of suboptimal water, sanitation, and hygiene, and the risk of typhoid fever outbreaks in these settings, it is imperative that a typhoid vaccine be considered for introduction as a pragmatic preventive approach.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0593","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T15:00:31Z","timestamp":1657724431000},"page":"82-85","source":"Crossref","is-referenced-by-count":13,"title":["Outbreak of Typhoid Fever in Children of Urban Vellore: A Report from the Surveillance for Enteric Fever in India Cohort"],"prefix":"10.4269","volume":"107","author":[{"given":"Manikandan","family":"Srinivasan","sequence":"first","affiliation":[{"name":"Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamilnadu, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kulandaipalayam Natarajan","family":"Sindhu","sequence":"additional","affiliation":[{"name":"Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamilnadu, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Senthil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamilnadu, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjith Kumar","family":"Ramasamy","sequence":"additional","affiliation":[{"name":"Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamilnadu, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agila Kumari","family":"Pragasam","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Christian Medical College, Vellore, Tamilnadu, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratheepa","family":"Aasaithampi","sequence":"additional","affiliation":[{"name":"Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamilnadu, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata Raghava","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Community Health, Christian Medical College, Vellore, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagandeep","family":"Kang","sequence":"additional","affiliation":[{"name":"Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamilnadu, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"John","sequence":"additional","affiliation":[{"name":"Department of Community Health, Christian Medical College, Vellore, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Clin Infect Dis","first-page":"S4","article-title":"Progress in typhoid fever epidemiology","volume":"15 (Suppl 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