{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T15:08:44Z","timestamp":1771859324656,"version":"3.50.1"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus endemic in many parts of the world. Because of migration, cases of HTLV-1 in non-HTLV-1 endemic countries have been increasingly reported. Clinical presentation of HTLV-1 infection is highly variable, with a significant risk of diagnostic delays. Skin can be the first site affected by HTLV-1-related manifestations such as cutaneous involvement of adult T-cell leukemia\/lymphoma (ATLL) and infective dermatitis associated with HTLV-1. A 32-year-old Nigerian man was admitted to the infectious disease department for high fever, asthenia, lymphocytosis, and vesicular bullous lesions on both hand palms and lower limbs. After clinical work-up was performed, bacterial superinfected herpes simplex viurs-2 ulcers were the presenting sign of HTLV-1-related chronic type ATLL. Standard treatment based on interferon-\u03b1 plus zidovudine was started, but it was poorly tolerated; therefore, switching to an off-label dual antiretroviral regimen was attempted. The increasing prevalence of HTLV-1 in nonendemic areas may enhance the development of alternative treatments with better efficacy and tolerability profiles.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0630","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T13:57:47Z","timestamp":1633960667000},"page":"1590-1593","source":"Crossref","is-referenced-by-count":5,"title":["Case Report: Atypical Cutaneous Presentation of Human T-cell Lymphotropic Virus Type 1-Related Adult T-cell Lymphoma"],"prefix":"10.4269","volume":"105","author":[{"given":"Gianluca","family":"Avallone","sequence":"first","affiliation":[{"name":"1Dermatology Clinic, Department of Medical Sciences University of Turin, Turin, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Trunfio","sequence":"additional","affiliation":[{"name":"2Unit of Infectious Diseases, Department of Medical Sciences, University of Turin at the Amedeo di Savoia Hospital, ASL Citt\u00e0 di Torino, Turin, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Mastorino","sequence":"additional","affiliation":[{"name":"1Dermatology Clinic, Department of Medical Sciences University of Turin, Turin, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Agostini","sequence":"additional","affiliation":[{"name":"1Dermatology Clinic, Department of Medical Sciences University of Turin, Turin, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Merli","sequence":"additional","affiliation":[{"name":"1Dermatology Clinic, Department of Medical Sciences University of Turin, Turin, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Rubatto","sequence":"additional","affiliation":[{"name":"1Dermatology Clinic, Department of Medical Sciences University of Turin, Turin, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Caracciolo","sequence":"additional","affiliation":[{"name":"3Division of Haematology, Department of Oncology, Azienda Ospedaliera Universitaria Citt\u00e0 della Salute e della Scienza di Torino, Presidio Molinette, Torino, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Calcagno","sequence":"additional","affiliation":[{"name":"2Unit of Infectious Diseases, Department of Medical Sciences, University of Turin at the Amedeo di Savoia Hospital, ASL Citt\u00e0 di Torino, Turin, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Senetta","sequence":"additional","affiliation":[{"name":"4Department of Oncology, Pathology Unit, University of Turin, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Fierro","sequence":"additional","affiliation":[{"name":"1Dermatology Clinic, Department of Medical Sciences University of Turin, Turin, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Quaglino","sequence":"additional","affiliation":[{"name":"1Dermatology Clinic, Department of Medical Sciences University of Turin, Turin, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Ribero","sequence":"additional","affiliation":[{"name":"1Dermatology Clinic, Department of Medical Sciences University of Turin, Turin, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/6\/article-p1590.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/105\/6\/article-p1590.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T23:02:24Z","timestamp":1638399744000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/105\/6\/article-p1590.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0630","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,1]]}}}