{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T16:40:14Z","timestamp":1649004014919},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,5]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>This study explored the contribution of viral respiratory infections (VRIs) in dengue-like illness (DLI) patients and their distinguishing clinicolaboratory parameters. Two hundred DLI patients were prospectively recruited (July 1\u2013 October 1, 2019) from a community clinic in Southern Malaysia. Patients \u2265 18 years with acute fever and fulfilling the WHO criteria of probable dengue were recruited. They underwent blood testing: blood counts, rapid dengue tests (nonstructural antigen-1\/IgM) and polymerase chain reaction (PCR) for dengue, Zika, chikungunya, and <jats:italic>Leptospira.<\/jats:italic> Nasopharyngeal swabs (NPSs) were collected for FilmArray<jats:sup>\u00ae<\/jats:sup>RP2plus testing. From the 200 NPSs, 58 respiratory viruses (RVs) were detected in 54 patients. Of the 96 dengue-confirmed cases, 86 had dengue mono-infection, and 10 were coinfected with RVs. Of the 104 nondengue, 44 were RV positive and 4 <jats:italic>Leptospira<\/jats:italic> positive. Zika and chikungunya virus were not detected. Overall, the etiological diagnosis was confirmed for 72% of patients. Clinicolaboratory parameters were compared between dengue mono-infection and VRI mono-infection. Patients with coinfections were excluded. Multiple logistic regression showed that recent household\/neighborhood history of dengue (adjusted odds ratio [aOR]: 5.9, 95% CI\u2009=\u20091.7\u201320.7), leukopenia (aOR: 12.5, 95% CI\u2009=\u20092.6\u201361.4) and thrombocytopenia (aOR: 5.5, 95% CI\u2009=\u20091.3\u201323.0) predicted dengue. Inversely, rhinorrhoea (aOR: 0.1, 95% CI\u2009=\u20090.01\u20130.3) and cough (aOR: 0.3, 95% CI\u2009=\u20090.1\u20130.9) favored VRI. Thus, VRIs comprise many infections diagnosed initially as DLIs. Early clinicolaboratory parameters can guide physicians screen patients for further testing.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0648","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T11:33:59Z","timestamp":1632742439000},"page":"187-191","source":"Crossref","is-referenced-by-count":0,"title":["Contribution of Viral Respiratory Infections to Dengue-Like Illness Presentation at a Community Clinic in Southern Malaysia"],"prefix":"10.4269","volume":"106","author":[{"given":"Amreeta","family":"Dhanoa","sequence":"first","affiliation":[{"name":"1Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Malaysia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin Fang","family":"Ngim","sequence":"additional","affiliation":[{"name":"1Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Malaysia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nor\u2019azim Mohd","family":"Yunos","sequence":"additional","affiliation":[{"name":"1Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Malaysia;"},{"name":"2Faculty of Medicine, University of Malaya, Malaysia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed M. Tupur","family":"Husain","sequence":"additional","affiliation":[{"name":"3United States Naval Medical Research Unit-2, Singapore;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian Yih","family":"Pong","sequence":"additional","affiliation":[{"name":"1Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Malaysia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan Fadhilah Wan","family":"Ismail","sequence":"additional","affiliation":[{"name":"4Mahmoodiah Health Clinic, Ministry of Health, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Hontz","sequence":"additional","affiliation":[{"name":"3United States Naval Medical Research Unit-2, Singapore;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharifah Syed","family":"Hassan","sequence":"additional","affiliation":[{"name":"1Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Malaysia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/1\/article-p187.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/106\/1\/article-p187.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T12:09:09Z","timestamp":1641384549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/1\/article-p187.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,5]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0648","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,5]]}}}