{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:33:58Z","timestamp":1791484438026,"version":"4.3.4"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,2]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Several Zika virus (ZIKV) seroprevalence studies have been conducted in Africa, Asia, Oceania, the Americas, and the Caribbean. However, studies on ZIKV seroprevalence are limited in Malaysia though several studies have shown that the disease is endemic in the Malaysian state of Sabah. To evaluate the seroprevalence of ZIKV infection, 818 serum samples were collected from febrile patients and healthy blood donors from the Kudat and Kota Kinabalu districts in Sabah from 2017 to 2018. They were screened for ZIKV infection by IgM and IgG ELISA, and positive ZIKV IgM samples were subjected to a 90% neutralization test for confirmation. Twenty-four (6% [95% CI 4 to 8]) confirmed and two (0.5% [95% CI 0.13 to 1.8]) probable ZIKV infections were detected among 400 febrile illness patients. Of 418 healthy blood donor samples, six (1.4% [95% CI 0.65 to 3]) were determined as confirmed ZIKV infections and six (1.4% [95% CI 0.65 to 3]) indicated probable ZIKV infection. This is the first study on the seroprevalence of ZIKV infections among patients and healthy blood donors in Sabah. Compared with previous studies in Malaysia, this study shows that the incidence of ZIKV infection has increased. It also suggests that a sero-surveillance system is essential to determine the circulation of ZIKV in Sabah, Malaysia.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0802","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T23:11:37Z","timestamp":1637622697000},"page":"601-606","source":"Crossref","is-referenced-by-count":5,"title":["Serological Evidence of Zika Virus Infection in Febrile Patients and Healthy Blood Donors in Sabah, Malaysian Borneo, 2017\u20132018"],"prefix":"10.4269","volume":"106","author":[{"given":"Mya Myat","family":"Ngwe Tun","sequence":"first","affiliation":[{"name":"1Department of Virology, Institute of Tropical Medicine and Leading Program, Nagasaki University, Nagasaki, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Mori","sequence":"additional","affiliation":[{"name":"2Department of Pathology and Microbiology, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahnaz Binti","family":"Sabri","sequence":"additional","affiliation":[{"name":"3Department of Transfusion Medicine, Queen Elizabeth Hospital II, Ministry of Health Malaysia, Kota Kinabalu, Sabah, Malaysia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Kugan","sequence":"additional","affiliation":[{"name":"4Putatan District Health Office, Ministry of Health Malaysia, Putatan, Sabah, Malaysia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saliz Binti","family":"Shaharom","sequence":"additional","affiliation":[{"name":"3Department of Transfusion Medicine, Queen Elizabeth Hospital II, Ministry of Health Malaysia, Kota Kinabalu, Sabah, Malaysia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jecelyn","family":"John","sequence":"additional","affiliation":[{"name":"5Borneo Medical and Health Research Center, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aung Min","family":"Soe","sequence":"additional","affiliation":[{"name":"1Department of Virology, Institute of Tropical Medicine and Leading Program, Nagasaki University, Nagasaki, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khine Mya","family":"Nwe","sequence":"additional","affiliation":[{"name":"1Department of Virology, Institute of Tropical Medicine and Leading Program, Nagasaki University, Nagasaki, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiloris Frederick","family":"Dony","sequence":"additional","affiliation":[{"name":"6Kota Kinabalu Public Health Laboratory, Sabah State Health Department, Ministry of Health Malaysia, Kota Kinabalu, Sabah, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Inoue","sequence":"additional","affiliation":[{"name":"1Department of Virology, Institute of Tropical Medicine and Leading Program, Nagasaki University, Nagasaki, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouichi","family":"Morita","sequence":"additional","affiliation":[{"name":"1Department of Virology, Institute of Tropical Medicine and Leading Program, Nagasaki University, Nagasaki, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamruddin","family":"Ahmed","sequence":"additional","affiliation":[{"name":"2Department of Pathology and Microbiology, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia;"},{"name":"5Borneo Medical and Health Research Center, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/2\/article-p601.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/106\/2\/article-p601.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T14:59:02Z","timestamp":1643813942000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/2\/article-p601.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,2]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0802","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,2]]}}}