{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T18:13:30Z","timestamp":1657736010045},"reference-count":35,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,13]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Substandard and falsified medicines are an enormous threat to global health. Poor quality antibiotic preparations contribute to the development of antimicrobial resistance. In surgery, where the occurrence of healthcare-associated infections is high, healthcare teams need to rely on the quality of antibiotic prophylaxis to prevent infections. We assessed the quality of antibiotics used for surgical infection prophylaxis in Benin. Thirty-three samples were collected from six hospitals located in various departments in Benin. The antibiotics (powders for injection: amoxicillin + clavulanic acid, ampicillin, ceftriaxone; solutions for injection: ciprofloxacin, gentamicin, metronidazole) were assessed using visual inspection, pharmacotechnical tests (including uniformity of mass, pH measure, sterility test, and active pharmaceutical ingredient identification), and assay tests (including a simple analytical method thin layer chromatography) and complex analytical techniques (ultraviolet-visible spectrophotometry, high-performance liquid chromatography\u2014diode-array detection, conductometry). Because the material needed for the methods recommended by the pharmacopeias to assess the dosage of gentamicin was not available, we developed and validated a conductometry method. Results showed that 97% (<jats:italic>n<\/jats:italic> = 32) of the samples passed visual inspection; 100% (<jats:italic>n<\/jats:italic> = 33) of the samples passed the pharmacotechnical tests, identification of active ingredients, and sterility test; 88% (<jats:italic>n <\/jats:italic>= 29) passed the test for percentage of active pharmaceutical ingredients. Overall, 15% of the samples did not pass the quality test (3% on visual inspection and 12% for excess active ingredients). Although most of the samples passed the quality tests, it appears important to perform routine quality control for intravenous medicines.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0844","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T13:21:16Z","timestamp":1654521676000},"page":"24-31","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of the Quality of Injectable Antibiotics in Benin"],"prefix":"10.4269","volume":"107","author":[{"given":"Ang\u00e8le Modup\u00e8","family":"Dohou","sequence":"first","affiliation":[{"name":"Louvain Drug Research Institute, Clinical Pharmacy, Universit\u00e9 Catholique de Louvain (UCLouvain), Belgium;"},{"name":"Laboratoire de Chimie Analytique et Analyse des M\u00e9dicaments, Universit\u00e9 d\u2019Abomey Calavi, B\u00e9nin;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achille Loconon","family":"Y\u00e9moa","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Analytique et Analyse des M\u00e9dicaments, Universit\u00e9 d\u2019Abomey Calavi, B\u00e9nin;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dodji Boris Aurel","family":"Guidan","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Analytique et Analyse des M\u00e9dicaments, Universit\u00e9 d\u2019Abomey Calavi, B\u00e9nin;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyive H\u00e9l\u00e8ne Solange","family":"Ahouandjinou","sequence":"additional","affiliation":[{"name":"Agence Nationale de Contr\u00f4le de Qualit\u00e9 des produits de sant\u00e9 et de l\u2019eau, Minist\u00e8re de la Sant\u00e9, Benin;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Amoussa","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Analytique et Analyse des M\u00e9dicaments, Universit\u00e9 d\u2019Abomey Calavi, B\u00e9nin;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis Mo\u00efse","family":"Dossou","sequence":"additional","affiliation":[{"name":"Service de Chirurgie G\u00e9n\u00e9rale, Centre Hospitalo-Universitaire D\u00e9partemental Ou\u00e9m\u00e9-Plateau, B\u00e9nin;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Marini Djang\u2019eing\u2019a","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, CIRM, Laboratory of Analytical Pharmaceutical Chemistry, University of Liege, Belgium;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Dalleur","sequence":"additional","affiliation":[{"name":"Louvain Drug Research Institute, Clinical Pharmacy, Universit\u00e9 Catholique de Louvain (UCLouvain), Belgium;"},{"name":"Pharmacy Department, Cliniques Universitaires Saint-Luc, UCLouvain, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"The World Medicines Situation 2011. 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