{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:31:24Z","timestamp":1781523084137,"version":"3.54.1"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,2]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Mass administration of ivermectin (IVM) has significantly reduced onchocerciasis prevalence, intensity, and morbidity in most endemic areas. Most IVM clinical trials were performed long ago in persons with high-intensity infections that are uncommon in West Africa today. This cohort treatment study recruited participants from a hypoendemic area in eastern Ghana to reevaluate the efficacy and tolerability of IVM with a special focus on the kinetics of microfilaria (Mf) clearance. Mf in the skin and anterior chambers (AC) were assessed by skin snip and slit lamp examinations at baseline and at 3 and 6 months after treatment with IVM 150\u2009\u03bcg\/kg. Most participants (184\u2013231, 79.7%) enrolled were treatment-na\u00efve. The baseline geometric mean skin Mf count was 12.67\/mg (range 3\u201386). Although persons with MfAC at baseline (64\/231, 27%) had significantly higher skin Mf counts than people without MfAC, 7 of 39 (15%) of persons with skin Mf counts in the range of 3\u20135\u2009Mf\/mg had MfAC. Skin Mf were detected in 14% (31\/218) and 45% (96\/216) of participants 3 and 6 months after IVM treatment, respectively. MfAC were detected in 12 of 212 (5.7%) study participants at 6 months. 81% (187 of 231) of participants experienced 439 adverse events within 7 days after treatment; all adverse events were mild (96.1%) or moderate. This study has provided new data on the kinetics of Mf in the skin and eyes after IVM treatment of persons with light to moderate intensity <jats:italic>Onchocerca volvulus<\/jats:italic> infections that are common in Africa at this time.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0859","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T17:27:52Z","timestamp":1638206872000},"page":"740-745","source":"Crossref","is-referenced-by-count":9,"title":["A Reevaluation of the Tolerability and Effects of Single-Dose Ivermectin Treatment on Onchocerca volvulus Microfilariae in the Skin and Eyes in Eastern Ghana"],"prefix":"10.4269","volume":"106","author":[{"given":"Nicholas O.","family":"Opoku","sequence":"first","affiliation":[{"name":"1School of Public Health, University of Health and Allied Sciences, Ho, Ghana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Gyasi","sequence":"additional","affiliation":[{"name":"2St. Thomas Eye Hospital, Accra, Ghana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Doe","sequence":"additional","affiliation":[{"name":"3Hohoe Municipal Hospital, Hohoe, Ghana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"Lew","sequence":"additional","affiliation":[{"name":"4Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustine R.","family":"Hong","sequence":"additional","affiliation":[{"name":"5Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sithembele","family":"Chithenga","sequence":"additional","affiliation":[{"name":"6Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter U.","family":"Fischer","sequence":"additional","affiliation":[{"name":"6Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"King","sequence":"additional","affiliation":[{"name":"7Center for Global Health and Diseases, Case-Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary J.","family":"Weil","sequence":"additional","affiliation":[{"name":"6Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/2\/article-p740.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/106\/2\/article-p740.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T14:58:10Z","timestamp":1643813890000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/2\/article-p740.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,2]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0859","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,2]]}}}