{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:24:41Z","timestamp":1764588281396},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,4]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>This study describes the clinical course of gastroenteritis caused by <jats:italic>Campylobacter<\/jats:italic> spp. as a single-infection versus coinfection and the corresponding changes that occur according to the treatment received, in children between 12 and 24 months of age. This descriptive study is based on the data of a pediatric cohort conducted between 2008 and 2011 of 555 children in Lima, Peru. Ninety-six diarrheal episodes with positive cultures for <jats:italic>Campylobacter<\/jats:italic> spp. were evaluated. In 52 episodes, empirical antibiotic treatment was started before pathogen isolation. Of these 96 episodes, 64.6% were coinfections with other pathogens. Coinfections were led by <jats:italic>Escherichia coli<\/jats:italic>, norovirus, and <jats:italic>Giardia<\/jats:italic>. Compared with single-infection episodes, coinfections had a mean symptom duration of 6.6 versus 5.7 days, a mean frequency of bowel movements per episode of 18.9 versus 14.8, and occurrence of vomiting and fever in 24.2% versus 14.7% of patients. Most of the patients with more severe clinical features at diagnosis were prescribed macrolides as empiric treatment. In the single-infection group, symptom duration was 7.2\u2009\u00b1\u20093.3 days in the macrolide-treated group and 7.9\u2009\u00b1\u20092.7 days in the nonmacrolide group. Diarrhea caused by coinfection appeared to be generally more severe than a single-pathogen. Patients with more severe clinical courses who received macrolides treatment might have had a faster recovery than patients who received nonmacrolides.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0881","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T12:34:16Z","timestamp":1647866056000},"page":"1384-1388","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Course of Children with Campylobacter Gastroenteritis With and Without Co-Infection in Lima, Peru"],"prefix":"10.4269","volume":"106","author":[{"given":"Galo Amaro","family":"Munoz","sequence":"first","affiliation":[{"name":"1School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maribel Denise","family":"Riveros-Ramirez","sequence":"additional","affiliation":[{"name":"1School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru;"},{"name":"2Medical Tropical Alexander von Humboldt Institute, Universidad Peruana Cayetano Heredia, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa","family":"Chea-Woo","sequence":"additional","affiliation":[{"name":"1School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa J.","family":"Ochoa","sequence":"additional","affiliation":[{"name":"1School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru;"},{"name":"2Medical Tropical Alexander von Humboldt Institute, Universidad Peruana Cayetano Heredia, Lima, Peru;"},{"name":"3Department of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/5\/article-p1384.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/106\/5\/article-p1384.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T11:39:58Z","timestamp":1651664398000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/5\/article-p1384.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,4]]},"references-count":0,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0881","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,4]]}}}