{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T20:30:25Z","timestamp":1778963425612,"version":"3.51.4"},"reference-count":34,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,14]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Highly effective vector control can reduce malaria burden significantly, but individuals with parasitemia provide a potential reservoir for onward transmission. We performed an empirical, non-parametric simulation based on cohort data from Tororo District, Uganda\u2014an area with historically high but recently reduced malaria transmission\u2014to estimate the effects of mass drug administration (MDA) and test-and-treat on parasite prevalence. We estimate that a single round of MDA would have accelerated declines in parasite prevalence dramatically over 2 years (cumulative parasite prevalence ratio [PPR], 0.34). This decline was mostly during the first year of administration (PPR, 0.23) and waned by 23 months (PPR, 0.74). Test-and-treat using a highly sensitive diagnostic had nearly the same effect as MDA at 1 year (PPR, 0.27) and required many fewer treatments. The impact of test-and-treat using a standard diagnostic was modest (PPR, 0.58 at 1 year). Our analysis suggests that in areas experiencing a dramatic reduction in malaria prevalence, MDA or test-and-treat with a highly sensitive diagnostic may be an effective way of reducing or eliminating the infectious reservoir temporarily. However, for sustained benefits, repeated rounds of the intervention or additional interventions are required.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0953","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T14:40:53Z","timestamp":1664808053000},"page":"1028-1035","source":"Crossref","is-referenced-by-count":4,"title":["Simulating the Impacts of Augmenting Intensive Vector Control with Mass Drug Administration or Test-and-Treat Strategies on the Malaria Infectious Reservoir"],"prefix":"10.4269","volume":"107","author":[{"given":"Joaniter I.","family":"Nankabirwa","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Makerere University College of Health Sciences, Kampala, Uganda;"},{"name":"Infectious Disease Research Collaboration, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Arinaitwe","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Collaboration, 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