{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T09:14:42Z","timestamp":1774084482644,"version":"3.50.1"},"reference-count":13,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,9]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Rapid diagnostic tests (RDTs) for <jats:italic>Plasmodium falciparum<\/jats:italic> commonly detect histidine-rich protein 2 (HRP-2), but HRP-2 deletions are increasingly recognized. We evaluated a prototype test detecting parasite lactate dehydrogenase (pLDH) and compared it to commercially available RDTs at a health facility in Uganda, using quantitative polymerase chain reaction as a gold standard. The prototype pLDH test had a high sensitivity for infections with at least 100 parasites\/\u00b5L (98%), comparable to HRP-2, and greater than an existing pLDH RDT (89%). Specificity for the prototype test was 99.5%, which is greater than the HRP-2 tests (93\u201395%). Therefore, the prototype pLDH test may be an attractive alternative malaria diagnostic.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0956","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T08:35:58Z","timestamp":1642667758000},"page":"850-852","source":"Crossref","is-referenced-by-count":4,"title":["A Novel Malaria Lateral Flow Assay for Detecting Plasmodium falciparum Lactate Dehydrogenase in Busia, Uganda"],"prefix":"10.4269","volume":"106","author":[{"given":"Christine M.","family":"Bachman","sequence":"first","affiliation":[{"name":"Global Health Laboratories, Bellevue, Washington;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Cate","sequence":"additional","affiliation":[{"name":"Global Health Laboratories, Bellevue, Washington;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Grant","sequence":"additional","affiliation":[{"name":"Global Health Laboratories, Bellevue, 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Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Olwoch","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayimuna","family":"Nalubega","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harriet","family":"Ochokoru","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Kasozi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Ategeka","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration, 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