{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:51:01Z","timestamp":1768287061980,"version":"3.49.0"},"reference-count":15,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,9]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Cutaneous leishmaniasis (CL) frequently entails chronic skin lesions that heal only slowly. Until now, the available therapeutic options are very limited. Here, we present a case of a 5\u00bd-year-old Syrian refugee with two progressive lower-leg skin ulcers caused by <jats:italic>Leishmania tropica<\/jats:italic>. The patient received topical treatment with LeiProtect<jats:sup>\u00ae<\/jats:sup>, a newly developed, hydroxypropylcellulose-based, filmogenic gel containing nontoxic concentrations of pharmaceutical sodium chlorite. The skin lesions completely healed within 8 weeks and did not relapse during 1 year of follow-up, underlining the efficacy of this novel local therapy of CL.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0962","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T07:43:34Z","timestamp":1641800614000},"page":"857-860","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Local Treatment of a Leishmania tropica Infection in a Syrian Child with a Novel Filmogenic Preparation of Pharmaceutical Sodium Chlorite (LeiProtect\u00ae)"],"prefix":"10.4269","volume":"106","author":[{"given":"Dirk","family":"Debus","sequence":"first","affiliation":[{"name":"Department of Dermatology, Paracelsus Medizinische Privatuniversit\u00e4t, Klinikum N\u00fcrnberg, Prof.-Ernst-Nathan-Stra\u00dfe 1, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semra","family":"Gen\u00e7","sequence":"additional","affiliation":[{"name":"Institute for Inorganic and Analytical Chemistry and Freiburg Material Research Center (FMF), Albert-Ludwigs-University Freiburg, Albertstra\u00dfe 21, Freiburg, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Kurz","sequence":"additional","affiliation":[{"name":"Institute for Inorganic and Analytical Chemistry and Freiburg Material Research Center (FMF), Albert-Ludwigs-University Freiburg, Albertstra\u00dfe 21, Freiburg, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Holzer","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy, Albert-Ludwigs-Universit\u00e4t, Hermann-Herder-Stra\u00dfe 9, Freiburg, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Bauer","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy, Albert-Ludwigs-Universit\u00e4t, Hermann-Herder-Stra\u00dfe 9, Freiburg, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"Heimke-Brinck","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Universit\u00e4tsklinikum Erlangen, Palmsanlage 3, Erlangen, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Baier","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Universit\u00e4tsklinikum Erlangen, Palmsanlage 3, Erlangen, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Sebald","sequence":"additional","affiliation":[{"name":"Mikrobiologisches Institut \u2013 Klinische Mikrobiologie, Immunologie und Hygiene, Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander-Universit\u00e4t (FAU) Erlangen-N\u00fcrnberg, Wasserturmstra\u00dfe 3\/5, Erlangen, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Debus","sequence":"additional","affiliation":[{"name":"Mikrobiologisches Institut \u2013 Klinische Mikrobiologie, Immunologie und Hygiene, Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander-Universit\u00e4t (FAU) Erlangen-N\u00fcrnberg, Wasserturmstra\u00dfe 3\/5, Erlangen, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Bogdan","sequence":"additional","affiliation":[{"name":"Mikrobiologisches Institut \u2013 Klinische Mikrobiologie, Immunologie und Hygiene, Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander-Universit\u00e4t (FAU) Erlangen-N\u00fcrnberg, Wasserturmstra\u00dfe 3\/5, Erlangen, Germany;"},{"name":"Medical Immunology Campus Erlangen, Friedrich-Alexander-Universit\u00e4t (FAU) Erlangen-N\u00fcrnberg, Schlossplatz 1, Erlangen, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt-Wilhelm","family":"Stahl","sequence":"additional","affiliation":[{"name":"Waisenmedizin e. V. Promoting Access to Care with Essential Medicine (PACEM), Non-Profit Non-Governmental Organization, G\u00fcnterstalstra\u00dfe 60, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Emerg Infect Dis","first-page":"1712","article-title":"Ongoing epidemic of cutaneous leishmaniasis among Syrian refugees, Lebanon","volume":"20","year":"2014"},{"key":"b2","series-title":"Acta Derm Venereol","first-page":"62","article-title":"Cutaneous leishmaniasis in Syria: clinical features, current status and the effects of war","volume":"95","year":"2015"},{"key":"b3","series-title":"WHO Reg Publ East Mediterr Ser","first-page":"1","article-title":"Manual for case management of cutaneous leishmaniasis in the WHO Eastern Mediterranean Region","volume":"35","year":"2014"},{"key":"b4","series-title":"Clin Infect Dis","first-page":"1148","article-title":"Efficacy of thermotherapy to treat cutaneous leishmaniasis caused by Leishmania tropica in Kabul, Afghanistan: a randomized, controlled trial","volume":"40","year":"2005"},{"key":"b5","series-title":"J Am Acad Dermatol","first-page":"271","article-title":"Leishmania tropica in children: a retrospective study","volume":"71","year":"2014"},{"key":"b6","series-title":"Can J Infect Dis Med Microbiol","first-page":"394","article-title":"Use of oral miltefosine for cutaneous leishmaniasis in Canadian soldiers returning from Afghanistan","volume":"19","year":"2008"},{"key":"b7","series-title":"Int J Dermatol","first-page":"281","article-title":"Comparative study of the efficacy of combined cryotherapy and intralesional meglumine antimoniate (Glucantime) vs. cryotherapy and intralesional meglumine antimoniate (Glucantime) alone for the treatment of cutaneous leishmaniasis","volume":"43","year":"2004"},{"key":"b8","series-title":"Australas J Dermatol","first-page":"e64","article-title":"Leishmania tropica successfully treated with photodynamic therapy","volume":"60","year":"2019"},{"key":"b9","series-title":"Clin Infect Dis","first-page":"370","article-title":"Travelers with cutaneous leishmaniasis cured without systemic therapy","volume":"57","year":"2013"},{"key":"b10","series-title":"BMC Infect Dis","first-page":"619","article-title":"A randomized controlled phase IIb wound healing trial of cutaneous leishmaniasis ulcers with 0.045% pharmaceutical chlorite (DAC N-055) with and without bipolar high frequency electro-cauterization versus intralesional antimony in Afghanistan","volume":"14","year":"2014"},{"key":"b11","series-title":"Am J Trop Med Hyg","first-page":"231","article-title":"Rhinophyma-like cutaneous leishmaniasis due to Leishmania aethiopica treated successfully with liposomal amphotericin B","volume":"100","year":"2019"},{"key":"b12","series-title":"PLoS Negl Trop Dis","first-page":"e2694","article-title":"Rapid healing of cutaneous leishmaniasis by high-frequency electrocauterization and hydrogel wound care with or without DAC N-055: a randomized controlled phase IIa trial in Kabul","volume":"8","year":"2014"},{"key":"b13","series-title":"Lancet","first-page":"825","article-title":"Rationale for and results from a randomised, double-blind trial of tetrachlorodecaoxygen anion complex in wound healing","volume":"1","year":"1986"},{"key":"b14","series-title":"Agents Actions","first-page":"368","article-title":"Anti-inflammatory properties of a novel wound healing and immunomodulating agent, tetrachlorodecaoxygen complex (TCDO)","volume":"31","year":"1990"},{"key":"b15","series-title":"J Pharmacol Exp Ther","first-page":"608","article-title":"Oxidative shielding or oxidative stress?","volume":"342","year":"2012"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/3\/article-p857.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/106\/3\/article-p857.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/106\/3\/article-p857.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:49:51Z","timestamp":1760964591000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/3\/article-p857.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,9]]},"references-count":15,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0962","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,9]]}}}