{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T09:07:31Z","timestamp":1716973651115},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,6]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Visceral leishmaniasis is treated with liposomal amphotericin B (L-AMB), which is associated with nephrotoxicity. Thus, we aimed to investigate nephrotoxicity through novel renal biomarkers in patients with visceral leishmaniasis during L-AMB use. Ours was a prospective study with 17 patients with visceral leishmaniasis treated with L-AMB during their hospital stay. Laboratory tests, renal parameters, urinary biomarkers (urinary kidney injury molecule 1, urinary monocyte chemoattractant protein 1 [uMCP-1], sodium\u2013potassium\u20132 chloride cotransporter [NKCC2], sodium\u2013hydrogen exchanger 3) [NHE3], aquaporin 2 [AQP2], tumor susceptibility gene 101 [TSH 101], and serum inflammatory biomarkers (MCP-1, interferon-\u03b3, and IL-6) were evaluated in two periods: before and during L-AMB use. Glomerular filtration rate, creatinine, proteinuria, and albuminuria were similar before and during L-AMB use. IL-6 levels, AQT2, and NHE3 expression decreased, whereas uMCP-1 and urinary kidney injury molecule 1 levels increased during L-AMB treatment. In patients who developed acute kidney injury, uMCP-1 showed higher levels. L-AMB aggravated tubuloglomerular lesions, inflammation, and renal tubular disorders. Thus, patients treated with L-AMB need to be monitored for inflammatory and electrolyte disturbances to prevent acute kidney injury, longer length of hospital stay, higher public costs, and mortality.<\/jats:p>","DOI":"10.4269\/ajtmh.21-0978","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T13:58:24Z","timestamp":1645451904000},"page":"1191-1195","source":"Crossref","is-referenced-by-count":3,"title":["Preliminary Study for New Markers of Early Tubuloglomerular Injury and Renal Inflammation in Patients with Visceral Leishmaniasis Receiving Liposomal Amphotericin B Treatment"],"prefix":"10.4269","volume":"106","author":[{"given":"Gabriela Freire","family":"Bezerra","sequence":"first","affiliation":[{"name":"1Pharmacology Postgraduate Program, Department of Physiology and Pharmacology, School of Medicine, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gdayllon Cavalcante","family":"Meneses","sequence":"additional","affiliation":[{"name":"2Medical Sciences Postgraduate Program, Department of Internal Medicine, School of Medicine, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitt\u00f3ria Nobre","family":"Jacinto","sequence":"additional","affiliation":[{"name":"2Medical Sciences Postgraduate Program, Department of Internal Medicine, School of Medicine, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danya Bandeira","family":"Lima","sequence":"additional","affiliation":[{"name":"3Clinical and Toxicological Analysis Department, School of Pharmacy, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuel Paula","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"3Clinical and Toxicological Analysis Department, School of Pharmacy, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lana Andrade Lucena","family":"Lima","sequence":"additional","affiliation":[{"name":"3Clinical and Toxicological Analysis Department, School of Pharmacy, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thaiany Pereira da","family":"Rocha","sequence":"additional","affiliation":[{"name":"3Clinical and Toxicological Analysis Department, School of Pharmacy, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella Evelyn Prado","family":"de Azevedo","sequence":"additional","affiliation":[{"name":"3Clinical and Toxicological Analysis Department, School of Pharmacy, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldo Bezerra","family":"da Silva Jr.","sequence":"additional","affiliation":[{"name":"4Collective Health Graduate Program, School of Medicine, Health Sciences Center, University of Fortaleza, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth De Francesco","family":"Daher","sequence":"additional","affiliation":[{"name":"2Medical Sciences Postgraduate Program, Department of Internal Medicine, School of Medicine, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice Maria Costa","family":"Martins","sequence":"additional","affiliation":[{"name":"1Pharmacology Postgraduate Program, Department of Physiology and Pharmacology, School of Medicine, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil;"},{"name":"3Clinical and Toxicological Analysis Department, School of Pharmacy, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/4\/article-p1191.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/106\/4\/article-p1191.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T12:38:26Z","timestamp":1649248706000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/4\/article-p1191.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,6]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-0978","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,6]]}}}