{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:52:07Z","timestamp":1787161927791,"version":"build-2736575974"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,9]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Hemoglobin C is the second most common structural hemoglobinopathy in Africa, and carriers have a reduced risk of severe malaria. However, the effect of HbAC on the antibody response to malaria antigens in pregnancy has not been studied. Here, we measured PfEMP1-specific antibodies in plasma samples from 74 Beninese pregnant women with either HbAA or HbAC. IgG-mediated inhibition of VAR2CSA\n                    <jats:sup>+<\/jats:sup>\n                    infected erythrocytes adhesion to chondroitin sulfate A (CSA) was also tested. PfEMP1-specific IgG levels to VAR2CSA were significantly lower in HbAC women, suggesting less exposure to VAR2CSA. In contrast, the percentage of VAR2CSA\n                    <jats:sup>+<\/jats:sup>\n                    -infected erythrocytes adhesion to CSA was not different between HbAA and HbAC women. Moreover, IgG levels to PfEMP1 variants associated with severe malaria were not significantly different between groups. The findings indicate similar exposure to\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    parasites expressing PfEMP1 variants causing severe malaria, and justify more comprehensive studies of hemoglobinopathy-related qualitative and quantitative differences in PfEMP1-specific antibody responses.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.21-1039","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T08:36:01Z","timestamp":1642667761000},"page":"853-856","source":"Crossref","is-referenced-by-count":2,"title":["Natural Acquired Immunity to Malaria Antigens among Pregnant Women with Hemoglobin C Trait"],"prefix":"10.4269","volume":"106","author":[{"given":"Mary","family":"Lopez-Perez","sequence":"first","affiliation":[{"name":"Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firmine","family":"Viwami","sequence":"additional","affiliation":[{"name":"UMR 261 MERIT, Universit\u00e9 de Paris, Institut de Recherche pour le D\u00e9veloppement (IRD), Paris, France;"},{"name":"Institut de Recherche Clinique du Benin, Abomey Calavi, Benin;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Doritchamou","sequence":"additional","affiliation":[{"name":"Institut de Recherche Clinique du Benin, Abomey Calavi, Benin;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicaise Tuikue","family":"Ndam","sequence":"additional","affiliation":[{"name":"UMR 261 MERIT, Universit\u00e9 de Paris, Institut de Recherche pour le D\u00e9veloppement (IRD), Paris, France;"},{"name":"Institut de Recherche Clinique du Benin, Abomey Calavi, Benin;"},{"name":"Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Hviid","sequence":"additional","affiliation":[{"name":"Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;"},{"name":"Centre for Medical Parasitology, Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"World Malaria Report 2020: 20 Years of Global Progress and Challenges","first-page":"299","year":"2020"},{"key":"b2","series-title":"J Exp Med","first-page":"1197","article-title":"Evidence for the involvement of VAR2CSA in pregnancy-associated malaria","volume":"200:","year":"2004"},{"key":"b3","series-title":"Cell Host Microbe","first-page":"403","article-title":"Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated 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Immun","first-page":"e00136","article-title":"IgG responses to the Plasmodium falciparum antigen VAR2CSA in Colombia are restricted to pregnancy and are not induced by exposure to Plasmodium vivax.","volume":"86:","year":"2018"},{"key":"b13","series-title":"PLoS Pathog","first-page":"e1005022","article-title":"alpha2-macroglobulin can crosslink multiple Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) molecules and may facilitate adhesion of parasitized erythrocytes","volume":"11:","year":"2015"},{"key":"b14","series-title":"Infect Immun","first-page":"e00224","article-title":"Acquisition of IgG to ICAM-1-binding DBLbeta domains in the Plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between groups A, B, and C","volume":"87:","year":"2019"},{"key":"b15","series-title":"Clin Diagn Lab Immunol","first-page":"30","article-title":"Antigenicity and immunogenicity of recombinant glutamate-rich protein of Plasmodium falciparum expressed in Escherichia coli.","volume":"2:","year":"1995"},{"key":"b16","author":"Lopez-Perez","year":"2021"},{"key":"b17","series-title":"Methods Mol Med","first-page":"555","article-title":"Analysis of CSA-binding parasites and antiadhesion antibodies","volume":"72:","year":"2002"},{"key":"b18","series-title":"Nature","first-page":"851","article-title":"Maternal antibodies block malaria","volume":"395:","year":"1998"},{"key":"b19","series-title":"J Immunol","first-page":"3309","article-title":"Plasma antibodies from malaria-exposed pregnant women recognize variant surface antigens on Plasmodium falciparum\u2013infected erythrocytes in a parity-dependent manner and block parasite adhesion to chondroitin sulfate A","volume":"165:","year":"2000"},{"key":"b20","series-title":"Open Forum Infect Dis","first-page":"ofz156","article-title":"Impact of hemoglobin S trait on cell surface antibody recognition of Plasmodium falciparum-infected erythrocytes in pregnancy-associated malaria","volume":"6:","year":"2019"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/3\/article-p853.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/106\/3\/article-p853.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/106\/3\/article-p853.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:48:05Z","timestamp":1760964485000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/3\/article-p853.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,9]]},"references-count":20,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-1039","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,9]]}}}