{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T07:51:49Z","timestamp":1779004309641,"version":"3.51.4"},"reference-count":40,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Malaria patients are at risk of cardiopulmonary complications but diagnosis and management can be difficult in resource-limited settings. B-lines on lung ultrasound (LUS) mark changes in lung density; however, little is known about their role in malaria. We aimed to examine the prevalence of B-lines in adults with malaria at baseline and follow-up compared with controls in the Amazon Basin. We also examined the relationship between B-lines and left ventricular ejection fraction. We performed eight-zone LUS, echocardiography, and blood smears in 94 adults (mean age 40 years, 54% men) with uncomplicated malaria and 449 controls without heart failure, renal insufficiency or lung disease (mean age 41 years, 38% men). Examinations of adults with malaria were repeated after antimalarial treatment, corresponding to a median of 30 days (interquartile range [IQR] 27\u201339). Adults with malaria suffered from <jats:italic>Plasmodium vivax<\/jats:italic> (<jats:italic>N<\/jats:italic> = 70, median 2,823 [IQR 598\u20137,698] parasites\/\u03bcL) or <jats:italic>P. falciparum<\/jats:italic> (<jats:italic>N<\/jats:italic> = 24, median 1,148 [IQR 480\u20133,128] parasites\/\u03bcL). At baseline, adults with malaria more frequently had \u2265 3 B-lines (summed across eight zones) compared with controls (30% versus 2%, <jats:italic>P<\/jats:italic> value &lt; 0.001), indicating higher lung density. When examinations were repeated, only 6% of adults with malaria had \u2265 3 B-lines at follow-up, which was significant lower compared with baseline (median reduction 3 B-lines; <jats:italic>P<\/jats:italic> value &lt; 0.001). B-lines were not significantly associated with left ventricular ejection fraction in adults with malaria. In conclusion, B-lines detected by LUS were more frequent in adults with uncomplicated malaria compared with controls and decreased after completed antimalarial treatment.<\/jats:p>","DOI":"10.4269\/ajtmh.21-1107","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T12:56:45Z","timestamp":1649681805000},"page":"1637-1645","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence and Dynamic Changes in Lung Ultrasound Findings among Adults with Uncomplicated Malaria and Controls in the Amazon Basin, Brazil"],"prefix":"10.4269","volume":"106","author":[{"given":"Alma","family":"Wegener","sequence":"first","affiliation":[{"name":"Multidisciplinary Center, Federal University of Acre, C\u00e2mpus Floresta, Cruzeiro do Sul, Acre, Brazil;"},{"name":"Department of Cardiology, Gentofte Hospital, Hellerup, Denmark;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna E.","family":"Holm","sequence":"additional","affiliation":[{"name":"Multidisciplinary Center, Federal University of Acre, C\u00e2mpus Floresta, Cruzeiro do Sul, Acre, Brazil;"},{"name":"Department of Cardiology, Gentofte Hospital, Hellerup, Denmark;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura C.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine O.","family":"Lima","sequence":"additional","affiliation":[{"name":"Multidisciplinary Center, Federal University of Acre, C\u00e2mpus Floresta, Cruzeiro do Sul, Acre, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luan O.","family":"Matos","sequence":"additional","affiliation":[{"name":"Multidisciplinary Center, Federal University of Acre, C\u00e2mpus Floresta, Cruzeiro do Sul, Acre, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle V. M.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Multidisciplinary Center, Federal University of Acre, C\u00e2mpus Floresta, Cruzeiro do Sul, Acre, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly Dam","family":"Kaagaard","sequence":"additional","affiliation":[{"name":"Multidisciplinary Center, Federal University of Acre, C\u00e2mpus Floresta, Cruzeiro do Sul, Acre, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Medeiros","family":"de Souza","sequence":"additional","affiliation":[{"name":"Multidisciplinary Center, Federal University of Acre, C\u00e2mpus Floresta, Cruzeiro do Sul, Acre, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Hviid","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Copenhagen University, Copenhagen, Denmark;"},{"name":"Department of Infectious Diseases, Rigshospitalet, Copenhagen University, Copenhagen, Denmark;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus Vin\u00edcius","family":"Guimar\u00e3es Lacerda","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lasse S.","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"National Malaria Reference Laboratory, Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio Romero","family":"Farias Marinho","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"Platz","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and 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