{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T01:20:20Z","timestamp":1783387220881,"version":"3.54.6"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>In malaria, rosetting is a phenomenon involving the cytoadherence of uninfected erythrocytes to infected erythrocytes (IRBC) harboring the late erythrocytic stage of <jats:italic>Plasmodium<\/jats:italic> spp. Recently, artesunate-stimulated rosetting has been demonstrated to confer a survival advantage to <jats:italic>P. falciparum<\/jats:italic> late-stage IRBC. This study investigated the rosetting response of <jats:italic>P. falciparum<\/jats:italic> and <jats:italic>P. vivax<\/jats:italic> clinical isolates to ex vivo antimalarial treatments. Brief exposure of IRBC to chloroquine, mefloquine, amodiaquine, quinine, and lumefantrine increased the rosetting rates of <jats:italic>P. falciparum<\/jats:italic> and <jats:italic>P. vivax<\/jats:italic>. Furthermore, the ex vivo combination of artesunate with mefloquine and piperaquine also resulted in increased the rosetting rates. Drug-mediated rosette-stimulation has important implications for the therapeutic failure of rapidly cleared drugs such as artesunate. However, further work is needed to establish the ramifications of increased rosetting rates by drugs with longer half-lifves, such as chloroquine, mefloquine, and piperaquine.<\/jats:p>","DOI":"10.4269\/ajtmh.21-1229","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T12:56:20Z","timestamp":1649681780000},"page":"1670-1674","source":"Crossref","is-referenced-by-count":6,"title":["Rosetting Responses of Plasmodium-infected Erythrocytes to Antimalarials"],"prefix":"10.4269","volume":"106","author":[{"given":"Wenn-Chyau","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Russell","sequence":"additional","affiliation":[{"name":"Infectious Diseases Labs (ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee-Ling","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Nosten","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Otago, Dunedin, Otago, New Zealand;"},{"name":"Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medical Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Tak, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"R\u00e9nia","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia;"},{"name":"Nuffield Department of Medicine, University of Oxford, United Kingdom;"},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University, 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