{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:00:46Z","timestamp":1781535646628,"version":"3.54.5"},"reference-count":15,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,17]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Intestinal capillariasis is an emerging fish-borne helminthic disease caused by the round worm <jats:italic>Capillaria philippinensis<\/jats:italic>. Chronic infection may lead to death if the disease is misdiagnosed and inappropriate treatment is given. We used a rapid lateral-flow immunochromatographic test for screening of intestinal capillariasis in patients with chronic diarrhea. We screened 292 chronic diarrhea patients who had visited hospitals in Thailand. Sixty-six (22.6%) cases were positive according to the kit. All positive patients received mebendazole at 200 mg twice per day for 30 consecutive days or albendazole at 200 mg twice per day for 10 consecutive days. Later, stool concentration techniques, used to examine stool samples from all serologically positive individuals on three consecutive days, revealed <jats:italic>C. philippinensis<\/jats:italic> eggs, larvae, and\/or adults. The kit is useful for screening and rapid diagnosis of intestinal capillariasis in chronic diarrhea patients in an endemic area for prevention of serious disease and facilitates treatment.<\/jats:p>","DOI":"10.4269\/ajtmh.21-1247","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T13:13:13Z","timestamp":1657026793000},"page":"370-372","source":"Crossref","is-referenced-by-count":3,"title":["High Prevalence of Intestinal Capillariasis in Chronic Diarrhea Patients in Thailand: Serological Screening Using a Rapid Lateral-Flow Immunochromatographic Assay"],"prefix":"10.4269","volume":"107","author":[{"given":"Thidarat K.","family":"Prasongdee","sequence":"first","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krongkaew","family":"Seesui","sequence":"additional","affiliation":[{"name":"Namphong Hospital, Khon Kaen, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuangphaka","family":"Sadee","sequence":"additional","affiliation":[{"name":"Clinical Immunology Unit, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakkhana","family":"Sadaow","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;"},{"name":"Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wattana","family":"Sukeepaisarnjaroen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratthaphol","family":"Kraiklang","sequence":"additional","affiliation":[{"name":"Department of Public Health Administration, Health Promotion, Nutrition, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oranuch","family":"Sanpool","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;"},{"name":"Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanchai","family":"Maleewong","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;"},{"name":"Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pewpan M.","family":"Intapan","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;"},{"name":"Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Int J Parasitol","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/S0020-7519(00)00122-3","article-title":"Emerging helminth zoonoses","volume":"30","year":"2000"},{"key":"b2","series-title":"Clin Microbiol Rev","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1128\/CMR.5.2.120","article-title":"Intestinal capillariasis","volume":"5","year":"1992"},{"key":"b3","series-title":"Clin Infect Dis","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1093\/clinids\/17.5.909","article-title":"Human intestinal capillariasis in an area of nonendemicity: case report and review","volume":"17","year":"1993"},{"key":"b4","series-title":"World J Gastroenterol","doi-asserted-by":"publisher","first-page":"506","DOI":"10.3748\/wjg.14.506","article-title":"Human intestinal capillariasis in Thailand","volume":"14","year":"2008"},{"key":"b5","series-title":"Am J Trop Med Hyg","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4269\/ajtmh.17-0465","article-title":"A hospital-based study of intestinal capillariasis in Thailand: clinical features, potential clues for diagnosis, and epidemiological characteristics of 85 patients","volume":"98","year":"2018"},{"key":"b6","series-title":"BMC Gastroenterol","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/s12876-014-0207-9","article-title":"Intestinal capillariasis in the 21st century: clinical presentations and role of endoscopy and imaging","volume":"14","year":"2014"},{"key":"b7","series-title":"Endoscopy","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1055\/s-0028-1119609","article-title":"Human intestinal capillariasis: diagnosis by jejunal fluid analysis obtained at enteroscopy and reversal of subtotal villous atrophy after treatment","volume":"41","year":"2009"},{"key":"b8","series-title":"PLOS ONE","doi-asserted-by":"publisher","first-page":"e0234746","DOI":"10.1371\/journal.pone.0234746","article-title":"Comparison of the diagnostic performance of microscopic examination, Copro-ELISA, and Copro-PCR in the diagnosis of Capillaria philippinensis infections","volume":"15","year":"2020"},{"key":"b9","series-title":"J Egypt Soc Parasitol","first-page":"97","article-title":"Evaluation of Capillaria philippinensis coproantigen in the diagnosis of infection","volume":"34","year":"2004"},{"key":"b10","series-title":"Parasitol Res","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s00436-005-0070-2","article-title":"Potential use of Trichinella spiralis antigen for serodiagnosis of human capillariasis philippinensis by immunoblot analysis","volume":"98","year":"2006"},{"key":"b11","series-title":"Acta Parasitol","doi-asserted-by":"publisher","first-page":"899","DOI":"10.2478\/s11686-020-00233-y","article-title":"Antigen recognition patterns of intestinal capillariasis using immunoblot-based serodiagnosis","volume":"65","year":"2020"},{"key":"b12","series-title":"Southeast Asian J Trop Med Public Health","first-page":"298","article-title":"An enzyme-linked immunosorbent assay as screening tool for human intestinal capillariasis","volume":"41","year":"2010"},{"key":"b13","series-title":"Parasitol Res","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1007\/s00436-017-5546-3","article-title":"Development and evaluation of a rapid diagnostic immunochromatographic device to detect antibodies in sera from intestinal capillariasis cases","volume":"116","year":"2017"},{"key":"b14","series-title":"Am J Trop Med Hyg","doi-asserted-by":"publisher","first-page":"810","DOI":"10.4269\/ajtmh.2006.74.810","article-title":"Human intestinal capillariasis (Capillaria philippinensis) in Taiwan","volume":"74","year":"2006"},{"key":"b15","series-title":"Trans R Soc Trop Med Hyg","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/0035-9203(86)90384-6","article-title":"The epidemiology and control of intestinal helminths in the Pulicat lake region of southern India. I. Study design and pre- and post-treatment observations on Ascaris lumbricoides infection","volume":"80","year":"1986"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/107\/2\/article-p370.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/107\/2\/article-p370.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/107\/2\/article-p370.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T13:35:33Z","timestamp":1660743333000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/107\/2\/article-p370.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,17]]},"references-count":15,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-1247","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,17]]}}}